ArticleJournal of materials science. Materials in medicine2015
Influence of 3D porous galactose containing PVA/gelatin hydrogel scaffolds on three-dimensional spheroidal morphology of hepatocytes.
Article in Journal of materials science. Materials in medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Freeze-Drying as a Tool for Preparing Porous Materials: From Proof of Concept to Recent Pharmaceutical Applications.AAPS PharmSciTech · 2025Review
- Challenges ofFrontiers in cell and developmental biology · 2025Review
- Patterned PVA Hydrogels with 3D Petri DishGels (Basel, Switzerland) · 2024Article
- Review
- Freeze-Drying Process for the Fabrication of Collagen-Based Sponges as Medical Devices in Biomedical Engineering.Materials (Basel, Switzerland) · 2023Review
- Three-Dimensional Spheroids as In Vitro Preclinical Models for Cancer Research.Pharmaceutics · 2020Review
- Regulated differentiation of stem cells into an artificial 3D liver as a transplantable source.Clinical and molecular hepatology · 2020Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Three-dimensional liver scaffolds are temporary framework that mimics native ECM architecture and positively influence hepatocyte lodging, proliferation with retention of metabolic activities. The aim of the current study is to develop galactose containing physical cross-linked polyvinyl alcohol/gelatin (P/G 8:2 and 9:1) hydrogel scaffolds via freeze/thaw technique. The 8:2 and 9:1 P/G hydrogels exhibited comparable pore size and porosity (P > 0.05). The tensile strength of the fabricated 8:2 and 9:1 P/G hydrogel scaffolds were found to be in accordance with native human liver. Pore interconnectivity of both the P/G hydrogel scaffolds was confirmed by scanning electron micrographs and liquid displacement method. Further galactose containing hydrogel promoted cell-cell and cell-hydrogel interaction, aiding cellular aggregation leading to spheroids formation compared to void P/G hydrogel by 7 days. Hence, galactose containing P/G hydrogel could be more promising substrate as it showed significantly higher cell proliferation and albumin secretion for 21 days when compared to non-galactose P/G hydrogels (P < 0.05).
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Registered trials
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