Evidence map›Paper›PMID 25578612›Full record

ArticleEnvironmental science and pollution research international2015

Combined chemical and toxicological evaluation of leachate from municipal solid waste landfill sites of Delhi, India.

Pooja Ghosh, Asmita Gupta, Indu Shekhar Thakur

Abstract read
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In one paragraph

Article in Environmental science and pollution research international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 104 citations in OpenAlex.

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  7. Genetic toxicity assessment using liver cell models: past, present, and future.Journal of toxicology and environmental health. Part B, Critical reviews · 2020
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Pooja GhoshSchool of Environmental Sciences, Jawaharlal Nehru University, New Delhi, 110067, India, pooja.ghosh9@gmail.com.
Asmita Gupta
Indu Shekhar Thakur
Jawaharlal Nehru University · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the present study, landfill leachate of three landfill sites of Delhi, India, was toxico-chemically analyzed for human risk assessment. Raw leachate samples were collected from the municipal solid waste (MSW) landfills of Delhi lacking liner systems. Samples were characterized with relatively low concentrations of heavy metals while the organic component exceeded the upper permissible limit by up to 158 times. Qualitative analysis showed the presence of numerous xenobiotics belonging to the group of halogenated aliphatic and aromatic compounds, polycyclic aromatic hydrocarbons (PAHs), phthalate esters, and other emerging contaminants. Quantitative analysis of PAHs showed that the benzo(a)pyrene-toxic equivalence quotient (BaP-TEQ) ranged from 41.22 to 285.557 ng L(-1). The human risk assessment methodology employed to evaluate the potential adverse effects of PAHs showed that the cancer risk level was lower than the designated acceptable risk of 10(-6). However, significant cytotoxic and genotoxic effects of leachates on HepG2 cell line was observed with MTT EC50 value ranging from 11.58 to 20.44 % and statistically significant DNA damage. Thus, although the leachates contained low concentrations of PAHs with proven carcinogenic potential, but the mixture of contaminants present in leachates are toxic enough to cause synergistic or additive cytotoxicity and genotoxicity and affect human health.

Indexed as

Carcinogenicity TestsCell SurvivalComet AssayGas Chromatography-Mass SpectrometryGroundwaterHep G2 CellsHumansIndiaMetals, HeavyOrganic ChemicalsPolycyclic Aromatic HydrocarbonsRisk AssessmentSpectrophotometry, AtomicWaste Disposal FacilitiesWater Pollutants, ChemicalMetals, HeavyOrganic ChemicalsPolycyclic Aromatic HydrocarbonsWater Pollutants, Chemical

Identifiers

PMID25578612
OpenAlexW2146575406

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.