ArticleJournal of assisted reproduction and genetics2015
Lack of association between genetic polymorphisms in three folate-related enzyme genes and male infertility in the Chinese population.
Article in Journal of assisted reproduction and genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 7 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- MTHFR C677T、MTHFR A1298C、MTRR A66G and MTR A2756G polymorphisms and male infertility risk: a systematic review and meta-analysis.Reproductive biology and endocrinology : RB&E · 2024Pooled it
- Methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and male infertility risk: An updated meta-analysis.Medicine · 2020Pooled it
- Association of the MTHFR 677C>T and 1298A>C polymorphisms and male infertility risk: a meta-analysis.Reproductive biology and endocrinology : RB&E · 2020Pooled it
- Contribution of MTR A2756G polymorphism and MTRR A66G polymorphism to the risk of idiopathic male infertility.Medicine · 2019Pooled it
- Association between MTHFR A1298C polymorphism and male infertility: A meta-analysis.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2017Pooled it
- MTHFR C677T, A1298C and MS A2756G Gene Polymorphisms and Male Infertility Risk in a Chinese Population: A Meta-Analysis.PloS one · 2017Pooled it
- Association ofAmerican journal of men's healthPooled it
- Safety and Efficacy of High-Dose Folinic Acid in Children with Autism: The Impact of Folate Metabolism Gene Polymorphisms.Nutrients · 2025Trial
- Association of folate metabolism gene polymorphisms with autism susceptibility and symptom severity in the Chinese population.World journal of psychiatry · 2025Article
- Xenobiotic metabolizing gene variants and the risk of male infertility - A systematic review, meta-analysis andToxicology reports · 2025Review
- Correlation of MTHFR C677T Polymorphism with Male Infertility among Indian Population: Case-Control Study.Journal of pharmacy & bioallied sciences · 2024Article
- MTHFR Gene-Polymorphism and Infertile Men in Indian Population: A Systematic Literature Review.Cureus · 2022Review
- MTHFR 1298A>C Substitution is a Strong Candidate for Analysis in Recurrent Pregnancy Loss: Evidence from 14,289 Subjects.Reproductive sciences (Thousand Oaks, Calif.) · 2022Review
- Article
- A Association ofInternational journal of fertility & sterility · 2021Article
- Analysis of spermatogenesis and fertility in adult mice with a hypomorphic mutation in the Mtrr gene.Reproduction, fertility, and development · 2019Article
- Methylenetetrahydrofolate Reductase C677T Polymorphism and Risk for Male Infertility in Asian Population.Indian journal of clinical biochemistry : IJCB · 2017Article
- Effect of folate deficiency on promoter methylation and gene expression of Esr1, Cav1, and Elavl1, and its influence on spermatogenesis.Oncotarget · 2017Article
- Association ofInternational journal of clinical and experimental pathology · 2017Article
- Association of polymorphisms in ART3 gene with male infertility in the Chinese population.International journal of clinical and experimental medicine · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis study explored the possible association of four single nucleotide polymorphisms (SNPs) of the three folate-related enzyme genes: MTHFR C677T and A1298C, MTR A2756G and MTRR A66G, with male infertility in the Chinese population.
methodsThe polymorphic distributions of the four SNPs (MTHFR C677T and A1298C, MTR A2756G and MTRR A66G) were investigated by the method of SNaPshot in a Chinese cohort including 296 idiopathic infertile males with azoospermia or oligozoospermia and 204 fertile males.
resultsWe found no evidence for an association between any of these variants (MTHFR C677T and A1298C, MTR A2756G and MTRR A66G) and male infertility.
conclusionsThere is no evidence for an association between male infertility and polymorphism of the three folate-related enzyme genes in the Chinese population.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.