ReviewMolecular plant2015
The application of synthetic biology to elucidation of plant mono-, sesqui-, and diterpenoid metabolism.
Review in Molecular plant, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Advancements in Crop PUFAs Biosynthesis and Genetic Engineering: A Systematic and Mixed Review System.International journal of molecular sciences · 2025Pooled it
- Divergent roles of ent-kaurene oxidase paralogs in rice momilactone biosynthesis.Journal of integrative plant biology · 2026Article
- Sesquiterpenoids fromMolecules (Basel, Switzerland) · 2026Article
- Harnessing plant agriculture to mitigate climate change: A framework to evaluate synthetic biology (and other) interventions.Plant physiology · 2025Article
- Review
- Plants against cancer: towards green Taxol production through pathway discovery and metabolic engineering.aBIOTECH · 2024Review
- LaMYC7, a positive regulator of linalool and caryophyllene biosynthesis, confers plant resistance toHorticulture research · 2024Article
- Comparative Analysis of Metabolome and Transcriptome in Different Tissue Sites ofMolecules (Basel, Switzerland) · 2024Article
- Unraveling the terpene synthase family and characterization of BsTPS2 contributing to (S)-( +)-linalool biosynthesis in Boswellia.Plant molecular biology · 2023Article
- Sustainable biosynthesis of valuable diterpenes in microbes.Engineering microbiology · 2023Review
- Functional characterization of Cinnamate 4-hydroxylase gene family in soybean (Glycine max).PloS one · 2023Article
- Anthocyanins, Carotenoids and Chlorophylls in Edible Plant Leaves Unveiled by Tandem Mass Spectrometry.Foods (Basel, Switzerland) · 2022Review
- Cytochrome P450-catalyzed biosynthesis of furanoditerpenoids in the bioenergy crop switchgrass (Panicum virgatum L.).The Plant journal : for cell and molecular biology · 2021Article
- Mining of theJournal of natural products · 2021Article
- Rice contains a biosynthetic gene cluster associated with production of the casbane-type diterpenoid phytoalexin ent-10-oxodepressin.The New phytologist · 2021Article
- Profiling of Volatile Compounds and Associated Gene Expression in TwoMolecules (Basel, Switzerland) · 2021Article
- Interdependent evolution of biosynthetic gene clusters for momilactone production in rice.The Plant cell · 2021Article
- Bioactive diterpenoid metabolism and cytotoxic activities of genetically transformed Euphorbia lathyris roots.Phytochemistry · 2020Article
- The foxtail millet (Setaria italica) terpene synthase gene family.The Plant journal : for cell and molecular biology · 2020Article
- Genomics-enabled analysis of specialized metabolism in bioenergy crops: current progress and challenges.Synthetic biology (Oxford, England) · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Plants synthesize a huge variety of terpenoid natural products, including photosynthetic pigments, signaling molecules, and defensive substances. These are often produced as complex mixtures, presumably shaped by selective pressure over evolutionary timescales, some of which have been found to have pharmaceutical and other industrial uses. Elucidation of the relevant biosynthetic pathways can provide increased access (e.g., via molecular breeding or metabolic engineering) and enable reverse genetic approaches toward understanding the physiological role of these natural products in plants as well. While such information can be obtained via a variety of approaches, this review describes the emerging use of synthetic biology to recombinantly reconstitute plant terpenoid biosynthetic pathways in heterologous host organisms as a functional discovery tool, with a particular focus on incorporation of the historically problematic cytochrome P450 mono-oxygenases. Also falling under the synthetic biology rubric and discussed here is the nascent application of genome-editing tools to probe physiological function.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.