Evidence map›Paper›PMID 25578035›Full record

ReviewCerebellum (London, England)2016

Asymmetries in Cerebellar Plasticity and Motor Learning.

Heather K Titley, Christian Hansel

Open access · greenAbstract readReview
In one paragraph

Review in Cerebellum (London, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Heather K TitleyDepartment of Neurobiology, University of Chicago, Chicago, IL, 60637, USA. htitley@uchicago.edu.
Christian HanselDepartment of Neurobiology, University of Chicago, Chicago, IL, 60637, USA.
University of Chicago · US

Funding

Intrinsic Plasticity and Information Storage in Cerebellar Purkinje CellsR01NS062771 · NINDS · UNIVERSITY OF CHICAGO · PI HANSEL, CHRISTIAN ROBERT · 2008 to 2023
$5.2M
Intrinsic Plasticity and Information Storage in Cerebellar Purkinje CellsR56NS062771 · NINDS · UNIVERSITY OF CHICAGO · PI HANSEL, CHRISTIAN ROBERT · 2019 to 2019
$555k
NINDS NIH HHS NS062771NINDS NIH HHS R01 NS062771NINDS NIH HHS R56 NS062771
6 · The paper itself

Abstract

Synaptic plasticity at the parallel fiber to Purkinje cell synapse has long been considered a cellular correlate for cerebellar motor learning. Functionally, long-term depression and long-term potentiation at these synapses seem to be the reverse of each other, with both pre- and post-synaptic expression occurring in both. However, different cerebellar motor learning paradigms have been shown to be asymmetric and not equally reversible. Here, we discuss the asymmetric reversibility shown in the vestibulo-ocular reflex and eyeblink conditioning and suggest that different cellular plasticity mechanisms might be recruited under different conditions leading to unequal reversibility.

Indexed as

AnimalsCerebellumHumansLearningLong-Term PotentiationNeuronal PlasticityPurkinje CellsSynapsesCerebellumEyeblink conditioningMotor learningPurkinje cellsSynaptic plasticityVestibulo-ocular reflex

Identifiers

PMID25578035
PMCPMC4500681
OpenAlexW1996178191

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.