Observational studyThe journal of allergy and clinical immunology. In practice
Oral food challenge and food allergy quality of life in caregivers of children with food allergy.
Observational study in The journal of allergy and clinical immunology. In practice. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03835767 (Prospective Study to Identify Food-Specific and Component IgE Threshold Levels That Predict Food Allergy in Patients With Elevated Total Serum IgE Levels and Atopic Dermatitis), which is not on this map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prospective Study to Identify Food-Specific and Component IgE Threshold Levels That Predict Food Allergy in Patients With Elevated Total Serum IgE Levels and Atopic Dermatitis
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Hospital-Based Food Challenges for the Diagnosis of Food Allergy-A BSACI Clinical Practice Statement.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2026Guideline
- Predictors of psychosocial burden in parents of children with food allergy.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2026Article
- Detection of Anaphylaxis Through the Cutaneous Barrier.Current allergy and asthma reports · 2025Review
- Effect of oral food challenge on quality of life and family activities in children with IgE-mediated food allergies.World journal of clinical pediatrics · 2025Article
- Article
- Innovation in Food Challenge Tests for Food Allergy.Current allergy and asthma reports · 2018Review
- Patient-Centered Outcomes in Food Allergy.Current allergy and asthma reports · 2017Review
- Quality of Life Among Food Allergic Patients and Their Caregivers.Current allergy and asthma reports · 2016Review
- Guidelines for the use and interpretation of diagnostic methods in adult food allergy.Clinical and molecular allergy : CMA · 2015Review
- 2015 update of the evidence base: World Allergy Organization anaphylaxis guidelines.The World Allergy Organization journal · 2015Article
- Evaluation of the measurement properties of the Brazilian version of two quality-of-life questionnaires in food allergy - for children and their parents.Jornal de pediatriaArticle
- Food Allergy Sensitization and Presentation in Siblings of Food Allergic Children.The journal of allergy and clinical immunology. In practiceArticle
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
backgroundFood allergy is associated with diminished patient and caregiver quality of life (QoL). Although oral food challenge (OFC) improves QoL of individuals with food allergy, its effects on caregiver QoL are unknown.
objectivesTo determine if differences in caregiver QoL exist based on their child undergoing OFC.
methodsCaregivers of individuals with food allergy who underwent OFCs between 2001 and 2012 at the University of Michigan Food Allergy Center completed the Food Allergy Quality of Life-Parental Burden index and a questionnaire that assessed details of the most-severe reaction by an individual with food allergy. Results were compared with 305 caregivers of individuals with food allergy who were unchallenged. All questionnaire data regarding the characteristics of the reactions of individuals with food allergy were verified through chart review.
resultsA total of 115 caregivers of individuals with food allergy who were undergoing OFC completed the QoL assessment. Caregivers of individuals with food allergy who were undergoing OFC had a significantly lower (better) QoL score than controls who were not challenged (1.5 vs 1.88; P = .02). Furthermore, within the challenged cohort, there was no significant difference in QoL score between those with a passing OFC (eg, non-reactive) and a failing OFC (eg, reactive) (1.42 vs 1.34; P = .83). In an adjusted linear regression model, the QoL score was significantly better among caregivers of individuals with food allergy who were undergoing OFC and with an income >$50,000 but significantly worsened for caregivers with multiple individuals with food allergy or if the individual with food allergy had atopic dermatitis.
conclusionThe caregiver QoL score is better with individuals with food allergy who underwent OFC versus controls who were unchallenged but not significantly different based on OFC outcome. QoL is, in addition, moderated by income, the presence of atopic dermatitis, and having multiple individuals with food allergy. OFC is associated with better caregiver QoL, irrespective of challenge outcome.
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Registered trials
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