Evidence map›Paper›PMID 25577446›Full record

ArticleJACC. Cardiovascular imaging2015

Increased extracellular volume and altered mechanics are associated with LVH in hypertensive heart disease, not hypertension alone.

Sujith Kuruvilla, Rajesh Janardhanan, Patrick Antkowiak, Ellen C Keeley, Nebiyu Adenaw, Jeremy Brooks, Frederick H Epstein, Christopher M Kramer, Michael Salerno

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Cardiovascular imaging, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04730882 (Effect of Postprandial Hyperglycemia on Vasculature in Type 1 Diabetes and Healthy Adults), which is not on this map. Cited by 85 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
85citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04730882 completednot on this mapstarted 2021, after this paper: background citation

Effect of Postprandial Hyperglycemia on Vasculature in Type 1 Diabetes and Healthy Adults

TypeobservationalSponsorUniversity of VirginiaRan2021 to 2024Enrolled36ConditionsType 1 Diabetes, Hyperglycemia, PostprandialArmsMixed Meal
3 · Its place in the literature

Who cites it

85 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
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  4. Native TJournal of magnetic resonance imaging : JMRI · 2018
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25 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Sujith KuruvillaDepartment of Medicine (Cardiology), Cardiovascular Imaging Center, University of Virginia Health System, Charlottesville, Virginia.
Rajesh JanardhananDepartment of Medicine (Cardiology), Cardiovascular Imaging Center, University of Virginia Health System, Charlottesville, Virginia.
Patrick AntkowiakDepartment of Radiology, Cardiovascular Imaging Center, University of Virginia Health System, Charlottesville, Virginia.
Ellen C KeeleyDepartment of Medicine (Cardiology), Cardiovascular Imaging Center, University of Virginia Health System, Charlottesville, Virginia.
Nebiyu AdenawDepartment of Radiology, Cardiovascular Imaging Center, University of Virginia Health System, Charlottesville, Virginia.
Jeremy BrooksDepartment of Radiology, Cardiovascular Imaging Center, University of Virginia Health System, Charlottesville, Virginia.
Frederick H EpsteinDepartment of Radiology, Cardiovascular Imaging Center, University of Virginia Health System, Charlottesville, Virginia; Department of Biomedical Engineering, Cardiovascular Imaging Center, University of Virginia Health System, Charlottesville, Virginia.
Christopher M KramerDepartment of Medicine (Cardiology), Cardiovascular Imaging Center, University of Virginia Health System, Charlottesville, Virginia; Department of Radiology, Cardiovascular Imaging Center, University of Virginia Health System, Charlottesville, Virginia.
Michael SalernoDepartment of Medicine (Cardiology), Cardiovascular Imaging Center, University of Virginia Health System, Charlottesville, Virginia; Department of Radiology, Cardiovascular Imaging Center, University of Virginia Health System, Charlottesville, Virginia; Department of Biomedical Engineering, Cardiovascular Imaging Center, University of Virginia Health System, Charlottesville, Virginia. Electronic address: ms5pc@virginia.edu.

Funding

Training in Cardiovascular Imaging ResearchT32EB003841 · NIBIB · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Jonathan R Lindner · 2004 to 2026
$4.4M
Quantitative Adenosine Stress CMR with Spiral Pulse SequencesK23HL112910 · NHLBI · UNIVERSITY OF VIRGINIA · PI SALERNO, MICHAEL · 2012 to 2016
$789k
Chemokines and Neovascularization in Coronary Artery DiseaseK23HL097074 · NHLBI · UNIVERSITY OF VIRGINIA · PI KEELEY, ELLEN CATHERINE · 2009 to 2013
$676k
NHLBI NIH HHS HL97074NHLBI NIH HHS K23 HL097074NHLBI NIH HHS K23 HL112910NIBIB NIH HHS 5T32EB003841NIBIB NIH HHS T32 EB003841
6 · The paper itself

Abstract

objectivesThe goal of this study was to assess the relationship among extracellular volume (ECV), native T1, and systolic strain in hypertensive patients with left ventricular hypertrophy (HTN LVH), hypertensive patients without LVH (HTN non-LVH), and normotensive controls.

backgroundDiffuse myocardial fibrosis in HTN LVH patients, as reflected by increased ECV and native T1, may be an underlying mechanism contributing to increased cardiovascular risk compared with HTN non-LVH subjects and controls. Furthermore, increased diffuse fibrosis in HTN LVH subjects may be associated with reduced peak systolic and early diastolic strain rate compared with the other 2 groups.

methodsT1 mapping was performed in 20 HTN LVH (mean age, 55 ± 11 years), 23 HTN non-LVH (mean age, 61 ± 12 years), and 22 control subjects (mean age, 54 ± 7 years) on a Siemens 1.5-T Avanto (Siemens Healthcare, Erlangen, Germany) using a previously validated modified look-locker inversion-recovery pulse sequence. T1 was measured pre-contrast and 10, 15, and 20 min after injection of 0.15 mmol/kg gadopentetate dimeglumine, and the mean ECV and native T1 were determined for each subject. Measurement of circumferential strain parameters were performed using cine displacement encoding with stimulated echoes.

resultsHTN LVH subjects had higher native T1 compared with controls (p < 0.05). HTN LVH subjects had higher ECV compared with HTN non-LVH subjects and controls (p < 0.05). Peak systolic circumferential strain and early diastolic strain rates were reduced in HTN LVH subjects compared with HTN non-LVH subjects and controls (p < 0.05). Increased levels of ECV and native T1 were associated with reduced peak systolic and early diastolic circumferential strain rate across all subjects.

conclusionsHTN LVH patients had higher ECV, longer native T1 and associated reduction in peak systolic circumferential strain, and early diastolic strain rate compared with HTN non-LVH and control subjects. Measurement of ECV and native T1 provide a noninvasive assessment of diffuse fibrosis in hypertensive heart disease.

Indexed as

Ventricular Function, LeftAdultAgedExtracellular MatrixFemaleFollow-Up StudiesHumansHypertensionHypertrophy, Left VentricularMagnetic Resonance Imaging, CineMaleMiddle AgedMyocardiumRetrospective Studiescardiac magnetic resonanceextracellular volumehypertensionhypertensive heart diseaseleft ventricular hypertrophymyocardial fibrosisT1 mapping

Identifiers

PMID25577446
PMCPMC4418794

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.