ArticleToxicological sciences : an official journal of the Society of Toxicology2015
Influence of particle size on persistence and clearance of aerosolized silver nanoparticles in the rat lung.
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Article in Toxicological sciences : an official journal of the Society of Toxicology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 1 pooled it
4.6field-weighted citation impact, top 4% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
43 citing papers in PubMed, 1 synthesis or guideline pooled it, 97 citations in OpenAlex.
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- New insights into the role of cellular senescence and chronic wounds.Frontiers in endocrinology · 2024Review
- Heterogeneous deposition of regular and mentholated little cigar smoke in the lungs of Sprague-Dawley rats.Particle and fibre toxicology · 2023Article
- Biokinetics of subacutely co-inhaled same size gold and silver nanoparticles.Particle and fibre toxicology · 2023Article
- Application of transgenic zebrafish for investigating inflammatory responses to nanomaterials: Recommendations for new users.F1000Research · 2023Review
- Application of chitosan/alginate nanoparticle in oral drug delivery systems: prospects and challenges.Drug delivery · 2022Review
- Enhanced silver nanoparticle-induced pulmonary inflammation in a metabolic syndrome mouse model and resolvin D1 treatment.Particle and fibre toxicology · 2022Article
- Inhalation of Silver Silicate Nanoparticles Leads to Transient and Differential Microglial Activation in the Rodent Olfactory Bulb.Toxicologic pathology · 2022Article
- Lung Models to Evaluate Silver Nanoparticles' Toxicity and Their Impact on Human Health.Nanomaterials (Basel, Switzerland) · 2022Review
- Modulation of Pulmonary Toxicity in Metabolic Syndrome Due to Variations in Iron Oxide Nanoparticle-Biocorona Composition.Nanomaterials (Basel, Switzerland) · 2022Article
- Kinetic time courses of inhaled silver nanoparticles in rats.Archives of toxicology · 2022Article
- Exposure Assessment of Silver and Gold Nanoparticles Generated During the Synthesis Process in a South African Research Laboratory.Frontiers in toxicology · 2022Article
- Disruption of pulmonary resolution mediators contribute to exacerbated silver nanoparticle-induced acute inflammation in a metabolic syndrome mouse model.Toxicology and applied pharmacology · 2021Article
- Pulmonary Exposure to Copper Oxide Nanoparticles Leads to Neurotoxicity via Oxidative Damage and Mitochondrial Dysfunction.Neurotoxicity research · 2021Article
- Translating nanoparticle dosimetry from conventionalJournal of aerosol science · 2021Article
- Biodistribution and pulmonary metabolic effects of silver nanoparticles in mice following acute intratracheal instillations.Environmental science and pollution research international · 2021Article
- Interactions of particulate matter and pulmonary surfactant: Implications for human health.Advances in colloid and interface science · 2020Review
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 1 country.
Donald S Anderson*Center for Health and the Environment, Department of Chemistry, Department of Mechanical and Aerospace Engineering, University of California Davis, Davis, California 95616, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Anschutz Medical Campus, Aurora, Colorado 80045, Department of Environmental Medicine, Langone Medical Center, New York University, Tuxedo, New York 10987, Department of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine, University of California Davis, Davis, California 95616 and Department of Pediatrics, School of Medicine, University of California Davis, Sacramento, California 95817.
Esther S Patchin*Center for Health and the Environment, Department of Chemistry, Department of Mechanical and Aerospace Engineering, University of California Davis, Davis, California 95616, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Anschutz Medical Campus, Aurora, Colorado 80045, Department of Environmental Medicine, Langone Medical Center, New York University, Tuxedo, New York 10987, Department of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine, University of California Davis, Davis, California 95616 and Department of Pediatrics, School of Medicine, University of California Davis, Sacramento, California 95817.
Rona M Silva*Center for Health and the Environment, Department of Chemistry, Department of Mechanical and Aerospace Engineering, University of California Davis, Davis, California 95616, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Anschutz Medical Campus, Aurora, Colorado 80045, Department of Environmental Medicine, Langone Medical Center, New York University, Tuxedo, New York 10987, Department of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine, University of California Davis, Davis, California 95616 and Department of Pediatrics, School of Medicine, University of California Davis, Sacramento, California 95817.
Dale L Uyeminami*Center for Health and the Environment, Department of Chemistry, Department of Mechanical and Aerospace Engineering, University of California Davis, Davis, California 95616, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Anschutz Medical Campus, Aurora, Colorado 80045, Department of Environmental Medicine, Langone Medical Center, New York University, Tuxedo, New York 10987, Department of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine, University of California Davis, Davis, California 95616 and Department of Pediatrics, School of Medicine, University of California Davis, Sacramento, California 95817.
Arjun Sharmah*Center for Health and the Environment, Department of Chemistry, Department of Mechanical and Aerospace Engineering, University of California Davis, Davis, California 95616, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Anschutz Medical Campus, Aurora, Colorado 80045, Department of Environmental Medicine, Langone Medical Center, New York University, Tuxedo, New York 10987, Department of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine, University of California Davis, Davis, California 95616 and Department of Pediatrics, School of Medicine, University of California Davis, Sacramento, California 95817.
Ting Guo*Center for Health and the Environment, Department of Chemistry, Department of Mechanical and Aerospace Engineering, University of California Davis, Davis, California 95616, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Anschutz Medical Campus, Aurora, Colorado 80045, Department of Environmental Medicine, Langone Medical Center, New York University, Tuxedo, New York 10987, Department of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine, University of California Davis, Davis, California 95616 and Department of Pediatrics, School of Medicine, University of California Davis, Sacramento, California 95817.
Gautom K Das*Center for Health and the Environment, Department of Chemistry, Department of Mechanical and Aerospace Engineering, University of California Davis, Davis, California 95616, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Anschutz Medical Campus, Aurora, Colorado 80045, Department of Environmental Medicine, Langone Medical Center, New York University, Tuxedo, New York 10987, Department of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine, University of California Davis, Davis, California 95616 and Department of Pediatrics, School of Medicine, University of California Davis, Sacramento, California 95817.
Jared M Brown*Center for Health and the Environment, Department of Chemistry, Department of Mechanical and Aerospace Engineering, University of California Davis, Davis, California 95616, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Anschutz Medical Campus, Aurora, Colorado 80045, Department of Environmental Medicine, Langone Medical Center, New York University, Tuxedo, New York 10987, Department of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine, University of California Davis, Davis, California 95616 and Department of Pediatrics, School of Medicine, University of California Davis, Sacramento, California 95817.
Jonathan Shannahan*Center for Health and the Environment, Department of Chemistry, Department of Mechanical and Aerospace Engineering, University of California Davis, Davis, California 95616, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Anschutz Medical Campus, Aurora, Colorado 80045, Department of Environmental Medicine, Langone Medical Center, New York University, Tuxedo, New York 10987, Department of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine, University of California Davis, Davis, California 95616 and Department of Pediatrics, School of Medicine, University of California Davis, Sacramento, California 95817.
Terry Gordon*Center for Health and the Environment, Department of Chemistry, Department of Mechanical and Aerospace Engineering, University of California Davis, Davis, California 95616, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Anschutz Medical Campus, Aurora, Colorado 80045, Department of Environmental Medicine, Langone Medical Center, New York University, Tuxedo, New York 10987, Department of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine, University of California Davis, Davis, California 95616 and Department of Pediatrics, School of Medicine, University of California Davis, Sacramento, California 95817.
Lung Chi Chen*Center for Health and the Environment, Department of Chemistry, Department of Mechanical and Aerospace Engineering, University of California Davis, Davis, California 95616, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Anschutz Medical Campus, Aurora, Colorado 80045, Department of Environmental Medicine, Langone Medical Center, New York University, Tuxedo, New York 10987, Department of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine, University of California Davis, Davis, California 95616 and Department of Pediatrics, School of Medicine, University of California Davis, Sacramento, California 95817.
Kent E Pinkerton*Center for Health and the Environment, Department of Chemistry, Department of Mechanical and Aerospace Engineering, University of California Davis, Davis, California 95616, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Anschutz Medical Campus, Aurora, Colorado 80045, Department of Environmental Medicine, Langone Medical Center, New York University, Tuxedo, New York 10987, Department of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine, University of California Davis, Davis, California 95616 and Department of Pediatrics, School of Medicine, University of California Davis, Sacramento, California 95817 *Center for Health and the Environment, Department of Chemistry, Department of Mechanical and Aerospace Engineering, University of California Davis, Davis, California 95616, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Anschutz Medical Campus, Aurora, Colorado 80045, Department of Environmental Medicine, Langone Medical Center, New York University, Tuxedo, New York 10987, Department of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine, University of California Davis, Davis, California 95616 and Department of Pediatrics, School of Medicine, University of California Davis, Sacramento, California 95817 *Center for Health and the Environment, Department of Chemistry, Department of Mechanical and Aerospace Engineering, University of California Davis, Davis, California 95616, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Anschutz Medical Campus, Aurora, Colorado 80045, Department of Environmental Medicine, Langone Medical Center, New York University, Tuxedo, New York 10987, Department of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine, University of California Davis, Davis, California 95616 and Department of Pediatrics, School of Medicine, University of California Davis, Sacramento, California 95817.
Laura S Van Winkle*Center for Health and the Environment, Department of Chemistry, Department of Mechanical and Aerospace Engineering, University of California Davis, Davis, California 95616, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Anschutz Medical Campus, Aurora, Colorado 80045, Department of Environmental Medicine, Langone Medical Center, New York University, Tuxedo, New York 10987, Department of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine, University of California Davis, Davis, California 95616 and Department of Pediatrics, School of Medicine, University of California Davis, Sacramento, California 95817 *Center for Health and the Environment, Department of Chemistry, Department of Mechanical and Aerospace Engineering, University of California Davis, Davis, California 95616, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Anschutz Medical Campus, Aurora, Colorado 80045, Department of Environmental Medicine, Langone Medical Center, New York University, Tuxedo, New York 10987, Department of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine, University of California Davis, Davis, California 95616 and Department of Pediatrics, School of Medicine, University of California Davis, Sacramento, California 95817 lsvanwinkle@ucdavis.edu.
University of Colorado Anschutz Medical Campus · USUniversity of California, Davis · USNew York University · US
Funding
Vaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ADRIANA HEGUY · 1985 to 2026
$83.1MWorkshop on Environmental Technology Transfer and EntrepreneurshipP42ES004699 · NIEHS · UNIVERSITY OF CALIFORNIA DAVIS · PI HAMMOCK, BRUCE D · 1987 to 2021
$50.1MTraining Program In Basic & Translational Cardiovascular ScienceT32HL086350 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Martin Cadeiras, David A. Liem · 2008 to 2026
$7.1MSynthesis and Characterization CoreU19ES019525 · NIEHS · RESEARCH TRIANGLE INSTITUTE · PI FENNELL, TIMOTHY RAYMOND · 2010 to 2014
$6.3MAcute and Chronic In vivo Effects of Engineered NanomaterialsU01ES020126 · NIEHS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI GORDON, TERRY · 2010 to 2014
$2.5MEngineered Nanomaterials: Linking Physical and Chemical Properties to BiologyU01ES020127 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI PINKERTON, KENT ED · 2010 to 2014
$2.5MNCI NIH HHS P30 CA016087NHLBI NIH HHS T32 HL086350NIEHS NIH HHS P42 ES004699NIEHS NIH HHS RFA ES-09-011NIEHS NIH HHS U01 ES020126NIEHS NIH HHS U01 ES020127NIEHS NIH HHS U19 ES019525PHS HHS 0H07550
Abstract
The growing use of silver nanoparticles (AgNPs) in consumer products raises concerns about potential health effects. This study investigated the persistence and clearance of 2 different size AgNPs (20 and 110 nm) delivered to rats by single nose-only aerosol exposures (6 h) of 7.2 and 5.4 mg/m(3), respectively. Rat lung tissue was assessed for silver accumulations using inductively-coupled plasma mass spectrometry (ICP-MS), autometallography, and enhanced dark field microscopy. Involvement of tissue macrophages was assessed by scoring of silver staining in bronchoalveolar lavage fluid (BALF). Silver was abundant in most macrophages at 1 day post-exposure. The group exposed to 20 nm AgNP had the greatest number of silver positive BALF macrophages at 56 days post-exposure. While there was a significant decrease in the amount of silver in lung tissue at 56 days post-exposure compared with 1 day following exposure, at least 33% of the initial delivered dose was still present for both AgNPs. Regardless of particle size, silver was predominantly localized within the terminal bronchial/alveolar duct junction region of the lung associated with extracellular matrix and within epithelial cells. Inhalation of both 20 and 110 nm AgNPs resulted in a persistence of silver in the lung at 56 days post-exposure and local deposition as well as accumulation of silver at the terminal bronchiole alveolar duct junction. Further the smaller particles, 20 nm AgNP, produced a greater silver burden in BALF macrophages as well as greater persistence of silver positive macrophages at later timepoints (21 and 56 days).
Indexed as
AerosolsParticle SizeAnimalsBronchoalveolar Lavage FluidLungMacrophagesMaleMetal NanoparticlesMicroscopy, Electron, TransmissionRatsRats, Sprague-DawleySilverAerosolsSilverengineered nanomaterialsinhalationinhaledlungmacrophage
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