Evidence map›Paper›PMID 25576992›Full record

ReviewLancet (London, England)2015

Rubella.

Nathaniel Lambert, Peter Strebel, Walter Orenstein, Joseph Icenogle, Gregory A Poland

Abstract readReview
In one paragraph

Review in Lancet (London, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 145 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
145citing papers in PubMed, 4 pooled it
15.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

145 citing papers in PubMed, 4 syntheses or guidelines pooled it, 295 citations in OpenAlex.

  1. Pooled it
  2. Vaccines for measles, mumps, rubella, and varicella in children.The Cochrane database of systematic reviews · 2021
    Pooled it
  3. Vaccines for measles, mumps, rubella, and varicella in children.The Cochrane database of systematic reviews · 2020
    Pooled it
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85 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 5 institutions in 2 countries.

Nathaniel LambertMayo Clinic Vaccine Research Group, Mayo Clinic, Rochester, MN, USA.
Peter StrebelDepartment of Immunization, Vaccines, and Biologicals, World Health Organization, Geneva, Switzerland.
Walter OrensteinEmory Vaccine Center, Emory University, Atlanta, GA, USA.
Joseph IcenogleNational Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Gregory A PolandMayo Clinic Vaccine Research Group, Mayo Clinic, Rochester, MN, USA; Program in Translational Immunovirology and Biodefense, Mayo Clinic, Rochester, MN, USA. Electronic address: poland.gregory@mayo.edu.
Centers for Disease Control and Prevention · USEmory University · USMayo Clinic in Arizona · USMayo Clinic in Florida · USWorld Health Organization · CH

Funding

Immunogenetic Mechanisms of Vaccine ResponseR37AI048793 · NIAID · MAYO CLINIC ROCHESTER · PI POLAND, GREGORY A. · 2011 to 2020
$5.4M
IMMUNOGENETIC MECHANISMS OF VACCINE RESPONSER01AI048793 · NIAID · MAYO CLINIC ROCHESTER · PI POLAND, GREGORY A. · 2001 to 2010
$4.3M
NIAID NIH HHS R01 AI048793NIAID NIH HHS R37 AI048793NIAID NIH HHS R37AI48793World Health Organization 001
6 · The paper itself

Abstract

Rubella remains an important pathogen worldwide, with roughly 100,000 cases of congenital rubella syndrome estimated to occur every year. Rubella-containing vaccine is highly effective and safe and, as a result, endemic rubella transmission has been interrupted in the Americas since 2009. Incomplete rubella vaccination programmes result in continued disease transmission, as evidenced by recent large outbreaks in Japan and elsewhere. In this Seminar, we provide present results regarding rubella control, elimination, and eradication policies, and a brief review of new laboratory diagnostics. Additionally, we provide novel information about rubella-containing vaccine immunogenetics and review the emerging evidence of interindividual variability in humoral and cell-mediated innate and adaptive immune responses to rubella-containing vaccine and their association with haplotypes and single-nucleotide polymorphisms across the human genome.

Indexed as

Antibody AffinityGlobal HealthHumansImmunity, InnateImmunogeneticsPolymorphism, GeneticPopulation SurveillanceRubellaRubella Syndrome, CongenitalViral VaccinesViral Vaccines

Identifiers

PMID25576992
PMCPMC4514442
OpenAlexW4210365593

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.