ArticleDevelopmental biology2015
Diverse ETS transcription factors mediate FGF signaling in the Ciona anterior neural plate.
Article in Developmental biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Comprehensive multi-omics integration identifies differentially active enhancers during human brain development with clinical relevance.Genome medicine · 2021Pooled it
- Pair-rule-like transcription patterns during neural tube closure in a proto-vertebrate.Development (Cambridge, England) · 2025Article
- Supracellular actomyosin assemblies: master coordinators of development.Development (Cambridge, England) · 2025Review
- Lhx3/4 initiates a cardiopharyngeal-specific transcriptional program in response to widespread FGF signaling.PLoS biology · 2024Article
- New developments in the biology of fibroblast growth factors.WIREs mechanisms of disease · 2022Review
- ERK signaling dissolves ERF repression condensates in living embryos.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Single-cell analysis of cell fate bifurcation in the chordate Ciona.BMC biology · 2021Article
- Genome-Wide Identification, Comparison, and Expression Analysis of Transcription Factors in AscidianInternational journal of molecular sciences · 2021Article
- Brain Sensory Organs of the AscidianFrontiers in cell and developmental biology · 2021Review
- Multiple inputs into a posterior-specific regulatory network in the Ciona notochord.Developmental biology · 2019Article
- Single-cell transcriptome profiling of the Ciona larval brain.Developmental biology · 2019Article
- Article
- Open chromatin dynamics reveals stage-specific transcriptional networks in hiPSC-based neurodevelopmental model.Stem cell research · 2018Article
- An FGF-driven feed-forward circuit patterns the cardiopharyngeal mesoderm in space and time.eLife · 2018Article
- Nodal and FGF coordinate ascidian neural tube morphogenesis.Development (Cambridge, England) · 2016Article
- Article
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Authors and funding
3 authors at 1 institution in 2 countries.
Funding
Abstract
The ascidian Ciona intestinalis is a marine invertebrate belonging to the sister group of the vertebrates, the tunicates. Its compact genome and simple, experimentally tractable embryos make Ciona well-suited for the study of cell-fate specification in chordates. Tunicate larvae possess a characteristic chordate body plan, and many developmental pathways are conserved between tunicates and vertebrates. Previous studies have shown that FGF signals are essential for neural induction and patterning at sequential steps of Ciona embryogenesis. Here we show that two different ETS family transcription factors, Ets1/2 and Elk1/3/4, have partially redundant activities in the anterior neural plate of gastrulating embryos. Whereas Ets1/2 promotes pigment cell formation in lateral lineages, both Ets1/2 and Elk1/3/4 are involved in the activation of Myt1L in medial lineages and the restriction of Six3/6 expression to the anterior-most regions of the neural tube. We also provide evidence that photoreceptor cells arise from posterior regions of the presumptive sensory vesicle, and do not depend on FGF signaling. Cells previously identified as photoreceptor progenitors instead form ependymal cells and neurons of the larval brain. Our results extend recent findings on FGF-dependent patterning of anterior-posterior compartments in the Ciona central nervous system.
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