ArticleDevelopmental biology2015
Tie1 is required for lymphatic valve and collecting vessel development.
Article in Developmental biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 45 citations in OpenAlex.
- TIE1-dependent lymphatic vascular remodeling is mediated by its second tyrosine kinase domain.Development (Cambridge, England) · 2025Article
- Lymphatic System Development and Function.Current cardiology reports · 2024Review
- Lymphangiogenesis requires Ang2/Tie/PI3K signaling for VEGFR3 cell-surface expression.The Journal of clinical investigation · 2022Article
- In vitro inhibition of cancer angiogenesis and migration by a nanobody that targets the orphan receptor Tie1.Cellular and molecular life sciences : CMLS · 2022Article
- Back and forth: History of and new insights on the vertebrate lymphatic valve.Development, growth & differentiation · 2021Review
- The lymphatics in kidney health and disease.Nature reviews. Nephrology · 2021Review
- Biochemical and mechanical signals in the lymphatic vasculature.Cellular and molecular life sciences : CMLS · 2021Review
- Article
- Loss of flow responsive Tie1 results in Impaired Aortic valve remodeling.Developmental biology · 2019Article
- Tie2 regulates endocardial sprouting and myocardial trabeculation.JCI insight · 2019Article
- Epidermal growth factor receptor promotes cerebral and retinal invasion by Toxoplasma gondii.Scientific reports · 2019Article
- Lymphatic Vessel Network Structure and Physiology.Comprehensive Physiology · 2018Review
- Intraluminal valves: development, function and disease.Disease models & mechanisms · 2017Review
- Intestinal lymphatic vasculature: structure, mechanisms and functions.Nature reviews. Gastroenterology & hepatology · 2017Review
- Elevated expression of Tie1 is accompanied by acquisition of cancer stemness properties in colorectal cancer.Cancer medicine · 2017Article
- Angiopoietin-Tie signalling in the cardiovascular and lymphatic systems.Clinical science (London, England : 1979) · 2017Review
- Tie1 controls angiopoietin function in vascular remodeling and inflammation.The Journal of clinical investigation · 2016Article
- Phosphorylation of Threonine 794 on Tie1 by Rac1/PAK1 Reveals a Novel Angiogenesis Regulatory Pathway.PloS one · 2015Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Tie1 is a receptor tyrosine kinase with broad expression in embryonic endothelium. Reduction of Tie1 levels in mouse embryos with a hypomorphic Tie1 allele resulted in abnormal lymphatic patterning and architecture, decreased lymphatic draining efficiency, and ultimately, embryonic demise. Here we report that Tie1 is present uniformly throughout the lymphatics and from late embryonic/early postnatal stages, becomes more restricted to lymphatic valve regions. To investigate later events of lymphatic development, we employed Cre-loxP recombination utilizing a floxed Tie1 allele and an Nfatc1Cre line, to provide loxP excision predominantly in lymphatic endothelium and developing valves. Interestingly, unlike the early prenatal defects previously described by ubiquitous endothelial deletion, excision of Tie1 with Nfatc1Cre resulted in abnormal lymphatic defects in postnatal mice and was characterized by agenesis of lymphatic valves and a deficiency of collecting lymphatic vessels. Attenuation of Tie1 signaling in lymphatic endothelium prevented initiation of lymphatic valve specification by Prox1 high expression lymphatic endothelial cells that is associated with the onset of turbulent flow in the lymphatic circulation. Our findings reveal a fundamental role for Tie1 signaling during lymphatic vessel remodeling and valve morphogenesis and implicate it as a candidate gene involved in primary lymphedema.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.