Evidence map›Paper›PMID 25576774›Full record

ReviewResearch in microbiology2015

Mobile genetic elements in Clostridium difficile and their role in genome function.

Peter Mullany, Elaine Allan, Adam P Roberts

Open access · hybridAbstract readReview
In one paragraph

Review in Research in microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 72 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Mobilome of Environmental Isolates ofAntibiotics (Basel, Switzerland) · 2025
    Article
  6. Article
  7. Article
  8. Molecular characterization and antibiotic resistance ofFood science and biotechnology · 2024
    Article
  9. Article
  10. Article
  11. Article
  12. Antibiotic Resistances of Clostridioides difficile.Advances in experimental medicine and biology · 2024
    Article
  13. Article
  14. Article
  15. Article
  16. Genomic evolution and virulence association ofEmerging microbes & infections · 2021
    Article
  17. Microorganisms · 2021
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Peter MullanyDepartment of Microbial Diseases, UCL Eastman Dental Institute, University College London, 256 Gray's Inn Road, London WC1X 8LD, UK. Electronic address: p.mullany@ucl.ac.uk.
Elaine AllanDepartment of Microbial Diseases, UCL Eastman Dental Institute, University College London, 256 Gray's Inn Road, London WC1X 8LD, UK. Electronic address: e.allan@ucl.ac.uk.
Adam P RobertsDepartment of Microbial Diseases, UCL Eastman Dental Institute, University College London, 256 Gray's Inn Road, London WC1X 8LD, UK. Electronic address: adam.roberts@ucl.ac.uk.
University College London · GB

Funding

Medical Research Council G0601176
6 · The paper itself

Abstract

Approximately 11% the Clostridium difficile genome is made up of mobile genetic elements which have a profound effect on the biology of the organism. This includes transfer of antibiotic resistance and other factors that allow the organism to survive challenging environments, modulation of toxin gene expression, transfer of the toxin genes themselves and the conversion of non-toxigenic strains to toxin producers. Mobile genetic elements have also been adapted by investigators to probe the biology of the organism and the various ways in which these have been used are reviewed.

Indexed as

Interspersed Repetitive SequencesAdaptation, BiologicalBacterial ToxinsClostridioides difficileGene Transfer, HorizontalGenome, BacterialBacterial ToxinsBacteriophageConjugative transposonHorizontal gene transferPaLocTn5397Tn916

Identifiers

PMID25576774
PMCPMC4430133
OpenAlexW2082716112

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.