ArticleAmerican journal of hypertension2015
Catheter-Based Radiofrequency Renal Denervation: Location Effects on Renal Norepinephrine.
Article in American journal of hypertension, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 2 syntheses or guidelines pooled it, 81 citations in OpenAlex.
- Efficacy and safety of renal denervation for the management of arterial hypertension: A systematic review and meta-analysis of randomized, sham-controlled, catheter-based trials.Journal of clinical hypertension (Greenwich, Conn.) · 2020Pooled it
- Renal Denervation for Resistant Hypertension in the contemporary era: A Systematic Review and Meta-analysis.Scientific reports · 2019Pooled it
- Renal Denervation in Asia: 2025 Asia Renal Denervation Consortium (ARDeC) Consensus Statement Endorsed by the Hypertension Cardiovascular Outcome Prevention and Evidence in Asia (HOPE Asia) Network.Hypertension (Dallas, Tex. : 1979) · 2026Review
- Sex-specific differences in the efficacy of renal denervation in patients with resistant hypertension depending on visceral obesity and kidney function.Frontiers in cardiovascular medicine · 2025Article
- Differential effects of renal denervation on skin and muscle sympathetic nerve traffic in resistant and uncontrolled hypertension.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2023Article
- Renal nerve stimulation identifies renal innervation and optimizes the strategy for renal denervation in canine.Journal of translational medicine · 2023Article
- The Effect of Renal Denervation on T Cells in Patients with Resistant Hypertension.International journal of molecular sciences · 2023Article
- Current Status and Future Perspectives of Renal Denervation.Korean circulation journal · 2021Review
- Obesity, kidney dysfunction, and inflammation: interactions in hypertension.Cardiovascular research · 2021Review
- Pulmonary and Systemic Hemodynamics following Multielectrode Radiofrequency Catheter Renal Denervation in Acutely Induced Pulmonary Arterial Hypertension in Swine.BioMed research international · 2021Article
- Catheter-Based Radiofrequency Renal Sympathetic Denervation Decreases Left Ventricular Hypertrophy in Hypertensive Dogs.Mediators of inflammation · 2021Article
- Effects of different ablation points of renal denervation on the efficacy of resistant hypertension.PeerJ · 2020Article
- Renal Innervation in Resistant Hypertension: A Review of Pathophysiology and Renal Denervation as Potential Treatment.Current hypertension reviews · 2020Review
- New data, new studies, new hopes for renal denervation in patients with uncontrolled hypertension.International Journal of Cardiology. Hypertension · 2019Review
- Selective renal denervation guided by renal nerve stimulation: mapping renal nerves for unmet clinical needs.Journal of human hypertension · 2019Article
- Procedural and Anatomical Determinants of Multielectrode Renal Denervation Efficacy.Hypertension (Dallas, Tex. : 1979) · 2019Article
- Obesity, kidney dysfunction and hypertension: mechanistic links.Nature reviews. Nephrology · 2019Review
- Atrial fibrillation reduction by renal sympathetic denervation: 12 months' results of the AFFORD study.Clinical research in cardiology : official journal of the German Cardiac Society · 2019Article
- Lessons Learned from RADIOSOUND-HTN: Different Technologies and Techniques for Catheter-based Renal Denervation and Their Effect on Blood Pressure.Interventional cardiology (London, England) · 2019Review
- 2019 Consensus Statement of the Taiwan Hypertension Society and the Taiwan Society of Cardiology on Renal Denervation for the Management of Arterial Hypertension.Acta Cardiologica Sinica · 2019Review
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundClinical studies indicate that blood pressure (BP)-lowering effects of radiofrequency (RF) renal denervation (RD) are sustained for up to 2 years, although a recent clinical trial failed to find a major effect compared to sham treatment. In most previous studies, the efficacy of RD has not been assessed. The current study determined whether RD in different regions of the renal artery causes different degrees of RD as assessed with renal norepinephrine (NE) levels. METHODS AND
resultsUnilateral RD was performed on 14 pigs divided into 3 groups: RD near the ostium, in the main renal artery near the bifurcation, and in extrarenal branches of the renal artery. After 2 weeks post-RD, the pigs were euthanized, renal cortex tissue was collected for NE measurement, and renal arteries were prepared for histological analysis. Renal NE decreased by 12% with RD at the ostium, 45% with RD near the bifurcation in the main renal artery, and 74% when RD was performed in extrarenal artery branches. The number of renal nerves was greatest in extrarenal branches and in the main artery compared to the ostium and the average distance from the lumen was greatest for nerves at the ostium and least at the branches.
conclusionsRF RD lowers renal NE more significantly when performed in branches of the renal artery closer to the kidney. Increased efficacy of RF RD in extrarenal arterial branches may be due to the greater number of nerves in close proximity to the artery lumen in the branches.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.