Evidence map›Paper›PMID 25576495›Full record

ArticleAmerican journal of preventive medicine2015

Total and cause-specific mortality of U.S. nurses working rotating night shifts.

Fangyi Gu, Jiali Han, Francine Laden, An Pan, Neil E Caporaso, Meir J Stampfer, Ichiro Kawachi, Kathryn M Rexrode, Walter C Willett, Susan E Hankinson and 2 more

3 registry-linked trialsAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of preventive medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 94 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
94citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05965609 nacompletednot on this mapstarted 2023, after this paper: background citation

Piloting an Adaption of Cognitive Behavioral Therapy for Insomnia for Shift Workers (CBTI-Shift)

TypeinterventionalSponsorOregon State UniversityRan2023 to 2026Enrolled60ConditionsCircadian Rhythm Sleep-Wake Disorders, Shift Work Type, Sleep Initiation and Maintenance DisordersArmsCBTI, MRTI
NCT05966805 nacompletednot on this mapstarted 2023, after this paper: background citation

Examining the Impact of a 12-week Worksite Exercise Training Intervention on Mental, Metabolic, Physical, Spiritual, and Occupational Well-being Among Acute Care Nurses: A Randomized, Controlled Mixed Methods Pilot Study

TypeinterventionalSponsorAdventHealthRan2023 to 2025Enrolled21ConditionsPsychological WellnessArmsExercise training group, Wait-List Control Group
NCT06384742 narecruitingnot on this mapstarted 2025, after this paper: background citation

Developing a Sleep Health Intervention for Shift Workers

TypeinterventionalSponsorOregon State UniversityRan2025 to 2028Enrolled60ConditionsShift Work Type Circadian Rhythm Sleep Disorder, Insomnia, PsychophysiologicalArmsShift Worker Intervention for Sleep Health
3 · Its place in the literature

Who cites it

94 citing papers in PubMed, 8 syntheses or guidelines pooled it.

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  13. Bolstering wellbeing and mitigating burnout in critical care: a mixed-methods exploration.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2026
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34 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Fangyi GuDivision of Cancer Epidemiology & Genetics, Genetic Epidemiology Branch, National Cancer Institute, Bethesda, Maryland.
Jiali HanChanning Division of Network Medicine, Harvard School of Public Health, Boston; Clinical Research Program, Department of Dermatology, Harvard School of Public Health, Boston; Department of Epidemiology, Richard M. Fairbanks School of Public Health, Simon Cancer Center, Indiana University, Indianapolis, Indiana.
Francine LadenDepartment of Environmental Health, Harvard School of Public Health, Boston; Department of Epidemiology, Harvard School of Public Health, Boston.
An PanSaw Swee Hock School of Public Health and Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore.
Neil E CaporasoDivision of Cancer Epidemiology & Genetics, Genetic Epidemiology Branch, National Cancer Institute, Bethesda, Maryland.
Meir J StampferChanning Division of Network Medicine, Harvard School of Public Health, Boston; Department of Epidemiology, Harvard School of Public Health, Boston.
Ichiro KawachiDepartment of Social and Behavioral Sciences, Harvard School of Public Health, Boston.
Kathryn M RexrodeDivision of Preventive Medicine, Harvard School of Public Health, Boston.
Walter C WillettDepartment of Nutrition, Harvard School of Public Health, Boston.
Susan E HankinsonChanning Division of Network Medicine, Harvard School of Public Health, Boston; Division of Biostatistics and Epidemiology, University of Massachusetts, Amherst, Massachusetts.
Frank E SpeizerChanning Division of Network Medicine, Harvard School of Public Health, Boston.
Eva S SchernhammerChanning Division of Network Medicine, Harvard School of Public Health, Boston; Division of Sleep Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Harvard School of Public Health, Boston; Applied Cancer Research-Institution for Translational Research Vienna (ACR-ITR VIEnna), Vienna, Austria. Electronic address: eva.schernhammer@channing.harvard.edu.

Funding

Statistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI TWOROGER, SHELLEY S · 2000 to 2019
$77.8M
Risk Factors for Breast Cancer in Younger NursesR01CA050385 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI ELIASSEN, A. HEATHER, WILLETT, WALTER C. · 1989 to 2019
$32.3M
Long Term Multidisciplinary Study of Cancer in Women: The Nurses Health StudyUM1CA186107 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIASSEN, A. HEATHER, STAMPFER, MEIR · 2014 to 2023
$22.3M
RISK FACTORS FOR CVD IN WOMENR01HL034594 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI JoAnn Elisabeth Manson, Lu Qi · 1985 to 2026
$13.8M
Clock Genes, Night Work, and Breast Cancer RiskR01CA114534 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI SCHERNHAMMER, EVA S · 2006 to 2008
$791k
ACL HHS R01OH009803Intramural NIH HHSNCI NIH HHS CA50385NCI NIH HHS CA87969NCI NIH HHS P01 CA087969NCI NIH HHS R01 CA050385NCI NIH HHS R01 CA114534NCI NIH HHS UM1 CA186107NHLBI NIH HHS HL034594NHLBI NIH HHS R01 HL034594NIOSH CDC HHS R01 OH009803
6 · The paper itself

Abstract

backgroundRotating night shift work imposes circadian strain and is linked to the risk of several chronic diseases. PURPOSE: To examine associations between rotating night shift work and all-cause; cardiovascular disease (CVD); and cancer mortality in a prospective cohort study of 74,862 registered U.S. nurses from the Nurses' Health Study.

methodsLifetime rotating night shift work (defined as ≥3 nights/month) information was collected in 1988. During 22 years (1988-2010) of follow-up, 14,181 deaths were documented, including 3,062 CVD and 5,413 cancer deaths. Cox proportional hazards models estimated multivariable-adjusted hazard ratios (HRs) and 95% CIs.

resultsAll-cause and CVD mortality were significantly increased among women with ≥5 years of rotating night shift work, compared to women who never worked night shifts. Specifically, for women with 6-14 and ≥15 years of rotating night shift work, the HRs were 1.11 (95% CI=1.06, 1.17) and 1.11 (95% CI=1.05, 1.18) for all-cause mortality and 1.19 (95% CI=1.07, 1.33) and 1.23 (95% CI=1.09, 1.38) for CVD mortality. There was no significant association between rotating night shift work and all-cancer mortality (HR≥15years=1.08, 95% CI=0.98, 1.19) or mortality of any individual cancer, with the exception of lung cancer (HR≥15years=1.25, 95% CI=1.04, 1.51).

conclusionsWomen working rotating night shifts for ≥5 years have a modest increase in all-cause and CVD mortality; those working ≥15 years of rotating night shift work have a modest increase in lung cancer mortality. These results add to prior evidence of a potentially detrimental effect of rotating night shift work on health and longevity.

Indexed as

Work Schedule ToleranceAdultAge FactorsCardiovascular DiseasesFemaleHealth BehaviorHumansLife StyleMiddle AgedNeoplasmsNursesProportional Hazards ModelsProspective StudiesRisk FactorsSocioeconomic FactorsTime Factors

Identifiers

PMID25576495
PMCPMC4339532

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.