ArticleNeurobiology of disease2015
Bursting activity of substantia nigra pars reticulata neurons in mouse parkinsonism in awake and anesthetized states.
Article in Neurobiology of disease, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 37 citations in OpenAlex.
- Astrocytes mediate the dopaminergic modulation of tonic GABAergic signaling in substantia nigra.Science advances · 2026Article
- Article
- Propagation of Oscillations in the Indirect Pathway of the Basal Ganglia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Oscillatory waveform sharpness asymmetry changes in motor thalamus and motor cortex in a rat model of Parkinson's disease.Experimental neurology · 2022Article
- Current approaches to characterize micro- and macroscale circuit mechanisms of Parkinson's disease in rodent models.Experimental neurology · 2022Review
- Motor cortico-nigral and cortico-entopeduncular information transmission and its modulation by buspirone in control and after dopaminergic denervation.Frontiers in pharmacology · 2022Article
- Input Zone-Selective Dysrhythmia in Motor Thalamus after Dopamine Depletion.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Disrupted basal ganglia output during movement preparation in hemiparkinsonian mice is consistent with behavioral deficits.Journal of neurophysiology · 2021Article
- Restoring lost nigrostriatal fibers in Parkinson's disease based on clinically-inspired design criteria.Brain research bulletin · 2021Review
- Premotor Ramping of Thalamic Neuronal Activity Is Modulated by Nigral Inputs and Contributes to Control the Timing of Action Release.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Dysregulation of external globus pallidus-subthalamic nucleus network dynamics in parkinsonian mice during cortical slow-wave activity and activation.The Journal of physiology · 2020Article
- Cellular and Synaptic Dysfunctions in Parkinson's Disease: Stepping out of the Striatum.Cells · 2019Review
- Population dynamics and entrainment of basal ganglia pacemakers are shaped by their dendritic arbors.PLoS computational biology · 2019Article
- Dopamine neurons encode performance error in singing birds.Science (New York, N.Y.) · 2016Article
- Effects of high-frequency stimulation of the internal pallidal segment on neuronal activity in the thalamus in parkinsonian monkeys.Journal of neurophysiology · 2016Article
- Cerebellar Nuclei Neurons Show Only Small Excitatory Responses to Optogenetic Olivary Stimulation in Transgenic Mice: In Vivo and In Vitro Studies.Frontiers in neural circuits · 2016Article
- Quantitative activation-induced manganese-enhanced MRI reveals severity of Parkinson's disease in mice.Scientific reports · 2015Article
- Nicotine Modifies Corticostriatal Plasticity and Amphetamine Rewarding Behaviors in Mice(1,2,3).eNeuroArticle
- Changes in Excitability Properties of Ventromedial Motor Thalamic Neurons in 6-OHDA Lesioned Mice.eNeuroArticle
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Electrophysiological changes in basal ganglia neurons are hypothesized to underlie motor dysfunction in Parkinson's disease (PD). Previous results in head-restrained MPTP-treated non-human primates have suggested that increased bursting within the basal ganglia and related thalamic and cortical areas may be a hallmark of pathophysiological activity. In this study, we investigated whether there is increased bursting in substantia nigra pars reticulata (SNpr) output neurons in anesthetized and awake, head-restrained unilaterally lesioned 6-OHDA mice when compared to control mice. Confirming previous studies, we show that there are significant changes in the firing rate and pattern in SNpr neuron activity under urethane anesthesia. The regular firing pattern of control urethane-anesthetized SNpr neurons was not present in the 6-OHDA-lesioned group, as the latter neurons instead became phase locked with cortical slow wave activity (SWA). Next, we examined whether such robust electrophysiological changes between groups carried over to the awake state. SNpr neurons from both groups fired at much higher frequencies in the awake state than in the anesthetized state and surprisingly showed only modest changes between awake control and 6-OHDA groups. While there were no differences in firing rate between groups in the awake state, an increase in the coefficient of variation (CV) was observed in the 6-OHDA group. Contrary to the bursting hypothesis, this increased CV was not due to changes in bursting but was instead due to a mild increase in pausing. Together, these results suggest that differences in SNpr activity between control and 6-OHDA lesioned mice may be strongly influenced by changes in network activity during different arousal and behavioral states.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.