Evidence map›Paper›PMID 25576382›Full record

ReviewExperimental cell research2015

Regulatory mechanisms that control mitotic kinesins.

Amber L Yount, Hailing Zong, Claire E Walczak

Open access · greenAbstract readReview
In one paragraph

Review in Experimental cell research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.5field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 45 citations in OpenAlex.

  1. Microtubule Engagement by the WD40-Containing Tail of Kinesin-4 KIF21B.bioRxiv : the preprint server for biology · 2026
    Article
  2. Article
  3. Article
  4. Mechanism and regulation of kinesin motors.Nature reviews. Molecular cell biology · 2025
    Review
  5. Article
  6. Article
  7. Fueling genome maintenance: On the versatile roles of NADThe Journal of biological chemistry · 2022
    Review
  8. Mud binds the kinesin-14 Ncd inBiochemistry and biophysics reports · 2021
    Article
  9. Article
  10. Review
  11. Article
  12. Frontiers in cellular and infection microbiology · 2020
    Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Amber L YountDepartment of Molecular and Cellular Biochemistry, Indiana University, Bloomington, IN 47405, United States.
Hailing ZongDepartment of Biology, Indiana University, Bloomington, IN 47405, United States.
Claire E WalczakMedical Sciences, Indiana University, Myers Hall 262, 915 East 3rd Street, Bloomington, IN 47405, United States. Electronic address: cwalczak@indiana.edu.
Indiana University Bloomington · US

Funding

Mechanisms of Spindle AssemblyR01GM059618 · NIGMS · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI WALCZAK, CLAIRE E · 1999 to 2016
$4.7M
NIGMS NIH HHS R01 GM059618NIGMS NIH HHS R01GM059618
6 · The paper itself

Abstract

During mitosis, the mitotic spindle is assembled to align chromosomes at the spindle equator in metaphase, and to separate the genetic material equally to daughter cells in anaphase. The spindle itself is a macromolecular machine composed of an array of dynamic microtubules and associated proteins that coordinate the diverse events of mitosis. Among the microtubule associated proteins are a plethora of molecular motor proteins that couple the energy of ATP hydrolysis to force production. These motors, including members of the kinesin superfamily, must function at the right time and in the right place to insure the fidelity of mitosis. Misregulation of mitotic motors in disease states, such as cancer, underlies their potential utility as targets for antitumor drug development and highlights the importance of understanding the molecular mechanisms for regulating their function. Here, we focus on recent progress about regulatory mechanisms that control the proper function of mitotic kinesins and highlight new findings that lay the path for future studies.

Indexed as

MitosisHumansKinesinsKinesins

Identifiers

PMID25576382
PMCPMC4433799
OpenAlexW2047380283

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.