ArticleMolecular biology and evolution2015
A Burst of miRNA Innovation in the Early Evolution of Butterflies and Moths.
Article in Molecular biology and evolution, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 41 citations in OpenAlex.
- A time course analysis through diapause reveals dynamic temporal patterns of microRNAs associated with endocrine regulation in the butterfly Pieris napi.Molecular ecology · 2025Article
- Noncoding RNAs have a key role in butterfly speciation. What about other flora and fauna?Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- A microRNA is the effector gene of a classic evolutionary hotspot locus.Science (New York, N.Y.) · 2024Article
- A micro-RNA is the effector gene of a classic evolutionary hotspot locus.bioRxiv : the preprint server for biology · 2024Article
- The genome and sex-dependent responses to temperature in the common yellow butterfly, Eurema hecabe.BMC biology · 2023Article
- ChIP-seq profiling of H3K4me3 and H3K27me3 in an invasive insect,Frontiers in genetics · 2023Article
- Diversity and Functional Roles of the Gut Microbiota in Lepidopteran Insects.Microorganisms · 2022Review
- A transcriptomic atlas underlying developmental plasticity of seasonal forms of Bicyclus anynana butterflies.Molecular biology and evolution · 2022Article
- FishmiRNA: An Evolutionarily Supported MicroRNA Annotation and Expression Database for Ray-Finned Fishes.Molecular biology and evolution · 2022Article
- Evolution after Whole-Genome Duplication: Teleost MicroRNAs.Molecular biology and evolution · 2021Article
- Large-Scale Annotation and Evolution Analysis of MiRNA in Insects.Genome biology and evolution · 2021Article
- Mimicry diversification inProceedings. Biological sciences · 2020Article
- Modulation and Evolution of Animal Development through microRNA Regulation of Gene Expression.Genes · 2019Review
- Well-Annotated microRNAomes Do Not Evidence Pervasive miRNA Loss.Genome biology and evolution · 2018Article
- Mirnovo: genome-free prediction of microRNAs from small RNA sequencing data and single-cells using decision forests.Nucleic acids research · 2017Article
- Comparative profiling of microRNAs in the winged and wingless English grain aphid, Sitobion avenae (F.) (Homoptera: Aphididae).Scientific reports · 2016Article
- Regulation of physiological processes by microRNAs in insects.Current opinion in insect science · 2015Article
- Evidence for the expression of abundant microRNAs in the locust genome.Scientific reports · 2015Article
- A Diversity of Conserved and Novel Ovarian MicroRNAs in the Speckled Wood (Pararge aegeria).PloS one · 2015Article
- A Uniform System for the Annotation of Vertebrate microRNA Genes and the Evolution of the Human microRNAome.Annual review of genetics · 2015Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
MicroRNAs (miRNAs) are involved in posttranscriptional regulation of gene expression. Because several miRNAs are known to affect the stability or translation of developmental regulatory genes, the origin of novel miRNAs may have contributed to the evolution of developmental processes and morphology. Lepidoptera (butterflies and moths) is a species-rich clade with a well-established phylogeny and abundant genomic resources, thereby representing an ideal system in which to study miRNA evolution. We sequenced small RNA libraries from developmental stages of two divergent lepidopterans, Cameraria ohridella (Horse chestnut Leafminer) and Pararge aegeria (Speckled Wood butterfly), discovering 90 and 81 conserved miRNAs, respectively, and many species-specific miRNA sequences. Mapping miRNAs onto the lepidopteran phylogeny reveals rapid miRNA turnover and an episode of miRNA fixation early in lepidopteran evolution, implying that miRNA acquisition accompanied the early radiation of the Lepidoptera. One lepidopteran-specific miRNA gene, miR-2768, is located within an intron of the homeobox gene invected, involved in insect segmental and wing patterning. We identified cubitus interruptus (ci) as a likely direct target of miR-2768, and validated this suppression using a luciferase assay system. We propose a model by which miR-2768 modulates expression of ci in the segmentation pathway and in patterning of lepidopteran wing primordia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.