Evidence map›Paper›PMID 25576232›Full record

ArticleEuropean radiology2015

Whole-body intravoxel incoherent motion imaging.

Lukas Filli, Moritz C Wurnig, Roger Luechinger, Christian Eberhardt, Roman Guggenberger, Andreas Boss

Abstract readEvaluation Study
PubMed Publisher
In one paragraph

Article in European radiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
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  4. Article
  5. Review
  6. Article
  7. Impact of b-Value Sampling Scheme on Brain IVIM Parameter Estimation in Healthy Subjects.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2020
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  19. [Cerebral lesions of DWI hyperintensity in patients with subacute stroke assessed by intravoxel incoherent motion technique].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2015
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lukas FilliDepartment of Radiology, University Hospital Zurich, Ramistrasse 100, 8091, Zurich, Switzerland, lukas.filli@usz.ch.
Moritz C Wurnig
Roger Luechinger
Christian Eberhardt
Roman Guggenberger
Andreas Boss

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo investigate the technical feasibility of whole-body intravoxel incoherent motion (IVIM) imaging. MATERIALS AND

methodsWhole-body MR images of eight healthy volunteers were acquired at 3T using a spin-echo echo-planar imaging sequence with eight b-values. Coronal parametrical whole-body maps of diffusion (D), pseudodiffusion (D*), and the perfusion fraction (Fp) were calculated. Image quality was rated qualitatively by two independent radiologists, and inter-reader reliability was tested with intra-class correlation coefficients (ICCs). Region of interest (ROI) analysis was performed in the brain, liver, kidney, and erector spinae muscle.

resultsDepiction of anatomic structures was rated as good on D maps and good to fair on D* and Fp maps. Exemplary mean D (10(-3) mm(2)/s), D* (10(-3) mm(2)/s) and Fp (%) values (± standard deviation) of the renal cortex were as follows: 1.7 ± 0.2; 15.6 ± 6.5; 20.9 ± 4.4. Inter-observer agreement was "substantial" to "almost perfect" (ICC = 0.80 - 0.92). The coefficient of variation of D* was significantly lower with the proposed algorithm compared to the conventional algorithm (p < 0.001), indicating higher stability.

conclusionThe proposed IVIM protocol allows computation of parametrical maps with good to fair image quality. Potential future clinical applications may include characterization of widespread disease such as metastatic tumours or inflammatory myopathies. KEY POINTS: • IVIM imaging allows estimation of tissue perfusion based on diffusion-weighted MRI. • In this study, a clinically suitable whole-body IVIM algorithm is presented. • Coronal parametrical whole-body maps showed good depiction of anatomic details. • Potential future applications include detection of widespread metastatic or inflammatory disease.

Indexed as

AdultAlgorithmsBrainDiffusion Magnetic Resonance ImagingEcho-Planar ImagingFeasibility StudiesFemaleHealthy VolunteersHumansKidneyLiverMotionNervous System DiseasesParaspinal MusclesPerfusionProspective Studies

Identifiers

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.