ArticleEuropean radiology2015
Iohexol versus diatrizoate for fecal/fluid tagging during CT colonography performed with cathartic preparation: comparison of examination quality.
Article in European radiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04582500 (Low-osmolar Contrast Tagging in Minimal Cathartic CT Colonography), which is not on this map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Low-osmolar Contrast Tagging in Minimal Cathartic CT Colonography
Who cites it
2 citing papers in PubMed, 11 citations in OpenAlex.
- Low-osmolar contrast tagging in minimally cathartic CT colonography for colorectal cancer screening: an observational study.Abdominal radiology (New York) · 2025Observational
- Objective and Subjective Intrapatient Comparison of Iohexol Versus Diatrizoate for Bowel Preparation Quality at CT Colonography.AJR. American journal of roentgenology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveWe aimed to compare iohexol vs. diatrizoate as fecal/fluid tagging agents for computed tomography colonography (CTC) regarding examination quality.
methodsForty prospective patients (M:F = 23:17; 63 ± 11.6 years) received CTC using 50 mL (350 mgI/mL) oral iohexol for tagging. Forty other indication-matched, age-matched, and sex-matched patients who underwent CTC using 100 mL diatrizoate for tagging and otherwise the same technique, were retrospectively identified. Two groups were compared regarding overall examination quality, per-patient and per-segment scores of colonic bubbles (0 [no bubbles] to 5 [the largest amount]), and the volume, attenuation, and homogeneity (untagged, layered, and homogeneous) of the residual colonic fluid.
resultsThe iohexol group demonstrated a greater amount of colonic bubbles than the diatrizoate group: mean per-patient scores ± SD of 1.2 ± 0.8 vs. 0.7 ± 0.6, respectively (p = 0.003); and rates of segments showing ≥ grade 3 bubbles of 12.9 % (85/659) vs. 1.6 % (11/695), respectively (p = 0.001). Residual colonic fluid amount standardized to the colonic volume did not significantly differ: 7.2 % ± 4.2 vs. 7.8 % ± 3.7, respectively (p = 0.544). Tagged fluid attenuation was mostly comparable between groups and the fluid was homogeneously tagged in 98.7 % (224/227) vs. 99.5 % (218/219) segments, respectively (p = 0.344). Iohexol caused more colonic bubbles when used during cathartic CTC. Otherwise, examination quality was similarly adequate with both iohexol and diatrizoate. KEY POINTS: • When used for tagging, iohexol caused significantly more colonic bubbles than diatrizoate. • The residual colonic fluid amount did not significantly differ between iohexol and diatrizoate. • The quality of fluid tagging was similarly adequate in both iohexol and diatrizoate.
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