SynthesisPharmacoEconomics2015
Cost-of-illness studies for bipolar disorder: systematic review of international studies.
Synthesis in PharmacoEconomics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) 2018 guidelines for the management of patients with bipolar disorder.Bipolar disorders · 2018Guideline
- Direct and indirect costs associated with declining distance visual acuity: A nationwide longitudinal cost-of-illness study with 11-year follow-up.Acta ophthalmologica · 2026Observational
- Cultural Adaptation of a Digital Mobile App for Bipolar Disorder (PolarUs): Protocol for a Qualitative Co-Design Study.JMIR research protocols · 2026Article
- Polygenic Risks for Mood Disorders and Economic Well-being: Study of Finnish Cohorts.Depression and anxiety · 2026Article
- Costs of psychotropics for outpatients with bipolar disorder in Japan; the MUSUBI 2016 survey.Annals of medicine · 2023Article
- Trial-based economic evaluation of mindfulness-based cognitive therapy compared to treatment as usual for bipolar disorder.International journal of methods in psychiatric research · 2023Article
- Opportunities for digital health technology: identifying unmet needs for bipolar misdiagnosis and depression care management.Frontiers in digital health · 2023Article
- Search for serum biomarkers in patients with bipolar disorder and major depressive disorder using metabolome analysis.Frontiers in psychiatry · 2023Article
- Genetic and functional analyses implicate microRNA 499A in bipolar disorder development.Translational psychiatry · 2022Article
- Obesity and metabolic comorbidity in bipolar disorder: do patients on lithium comprise a subgroup? A naturalistic study.BMC psychiatry · 2021Article
- The costs of bipolar disorder in the United Kingdom.Brain and behavior · 2021Article
- Real-World Patterns of Utilization and Costs Associated with Second-Generation Oral Antipsychotic Medication for the Treatment of Bipolar Disorder: A Literature Review.Neuropsychiatric disease and treatment · 2021Review
- The Economic Burden of Bipolar Disorder in the United States: A Systematic Literature Review.ClinicoEconomics and outcomes research : CEOR · 2020Review
- Personality Structure and Attachment in Bipolar Disorder.Frontiers in psychiatry · 2020Article
- Proteomic Profiling as a Diagnostic Biomarker for Discriminating Between Bipolar and Unipolar Depression.Frontiers in psychiatry · 2020Article
- FGF21 Is Associated with Metabolic Effects and Treatment Response in Depressed Bipolar II Disorder Patients Treated with Valproate.The international journal of neuropsychopharmacology · 2018Article
- Critical factors for the return-to-work process among people with affective disorders: Voices from two vocational approaches.Work (Reading, Mass.) · 2018Article
- Health status and mobility limitations are associated with residential and employment status in schizophrenia and bipolar disorder.Journal of psychiatric research · 2017Article
- A genome-wide quantitative trait locus (QTL) linkage scan of NEO personality factors in Latino families segregating bipolar disorder.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2017Article
- Roles of C-reactive protein polymorphisms and life event changes on cognitive function in bipolar patients receiving valproate.International journal of immunopathology and pharmacologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesBipolar disorder (BD) may result in a greater burden than all forms of cancer, Alzheimer's disease and epilepsy. Cost-of-illness (COI) studies provide useful information on the economic burden that BD imposes on a society. Furthermore, COI studies are pivotal sources of evidence used in economic evaluations. This study aims to give a general overview of COI studies for BD and to discuss methodological issues that might potentially influence results. This study also aims to provide recommendations to improve practice in this area, based on the review.
methodsA search was performed to identify COI studies of BD. The following electronic databases were searched: MEDLINE, EMBASE, PsycInfo, Cochrane Database of Systematic Reviews, HMIC and openSIGLE. The primary outcome of this review was the annual cost per BD patient. A narrative assessment of key methodological issues was also included. Based on these findings, recommendations for good practice were drafted.
resultsFifty-four studies were included in this review. Because of the widespread methodological heterogeneity among included studies, no attempt has been made to pool results of different studies. Potential areas for methodological improvement were identified. These were: description of the disease and population, the approach to deal with comorbidities, reporting the rationale and impact for choosing different cost perspectives, and ways in which uncertainty is addressed.
conclusionsThis review showed that numerous COI studies have been conducted for BD since 1995. However, these studies employed varying methods, which limit the comparability of findings. The recommendations provided by this review can be used by those conducting COI studies and those critiquing them, to increase the credibility and reporting of study results.
Indexed as
Identifiers
25576148What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.