ArticleEuropean journal of epidemiology2015
Maternal smoking during pregnancy and offspring type 1 diabetes mellitus risk: accounting for HLA haplotype.
Article in European journal of epidemiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Parental smoking, type 1 diabetes, and islet autoantibody positivity in the offspring: A systematic review and meta-analysis.Diabetic medicine : a journal of the British Diabetic Association · 2022Pooled it
- DNA Methylation Smoking Scores and Risk of Islet Autoimmunity and Type 1 Diabetes.Diabetes care · 2025Article
- A retrospective evaluation of parental smoking and the risk of Type 1 diabetes in children.Tobacco induced diseases · 2024Article
- Maternal smoking during pregnancy and type 1 diabetes in the offspring: a nationwide register-based study with family-based designs.BMC medicine · 2022Article
- Prenatal Effects of Nicotine on Obesity Risks: A Narrative Review.International journal of environmental research and public health · 2022Review
- Risk of Gestational Diabetes Due to Maternal and Partner Smoking.International journal of environmental research and public health · 2022Observational
- Epigenetic Changes Induced by Maternal Factors during Fetal Life: Implication for Type 1 Diabetes.Genes · 2021Review
- Effect of maternal smoking during pregnancy on childhood type 1 diabetes: a whole-of-population study.Diabetologia · 2020Article
- Association between Bioactive Molecules in Breast Milk and Type 1 Diabetes Mellitus.Sultan Qaboos University medical journal · 2020Review
- Smoking and pregnancy: Epigenetics and developmental origins of the metabolic syndrome.Birth defects research · 2019Review
- Parental Smoking and Risk of Childhood-onset Type 1 Diabetes.Epidemiology (Cambridge, Mass.) · 2018Article
- The role of gut microbiota in the effects of maternal obesity during pregnancy on offspring metabolism.Bioscience reports · 2018Review
- Gestational respiratory infections interacting with offspring HLA and CTLA-4 modifies incident β-cell autoantibodies.Journal of autoimmunity · 2018Article
- The Rotterdam Study: 2018 update on objectives, design and main results.European journal of epidemiology · 2017Article
- Developmental cigarette smoke exposure II: Hepatic proteome profiles in 6 month old adult offspring.Reproductive toxicology (Elmsford, N.Y.) · 2016Article
- Geographic Variation in Maternal Smoking during Pregnancy in the Missouri Adolescent Female Twin Study (MOAFTS).PloS one · 2016Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The main objective of this study was to investigate the risk of type 1 diabetes mellitus (T1D) in children exposed to tobacco smoking in utero, also taking genetic predisposition as expressed by HLA haplotype into account. In Skåne, the southernmost county of Sweden, all children born 1999-2005 who developed T1D were registered, resulting in 344 cases. For each child with T1D, three control children, matched for HLA haplotype and birthyear, were selected. Information on prenatal smoking exposure was retrieved from a regional birth register. Conditional logistic regressions were used to evaluate T1D risk following prenatal smoking exposure. In these data, maternal smoking in early pregnancy was associated with a higher risk of her child developing T1D [odds ratio (OR) 2.83; 95% confidence interval (CI) 1.67-4.80 for 1-9 cigarettes/day, and OR 3.91; 95% CI 1.22-12.51 for >9 cigarettes/day]. Results remained through all adjustments and sensitivity analyses. When genetic predisposition in terms of HLA haplotype was taken into account, we found that children exposed to smoking during fetal life were at higher risk of developing T1D in childhood.
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