Evidence map›Paper›PMID 25576051›Full record

ArticleDiabetes2015

miR-30 promotes thermogenesis and the development of beige fat by targeting RIP140.

Fang Hu, Min Wang, Ting Xiao, Bangqi Yin, Linyun He, Wen Meng, Meijuan Dong, Feng Liu

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetes, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
87citing papers in PubMed, 1 pooled it
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

87 citing papers in PubMed, 1 synthesis or guideline pooled it, 125 citations in OpenAlex.

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27 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Fang HuMetabolic Syndrome Research Center, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China Key Laboratory of Diabetes Immunology, Ministry of Education, Institute of Metabolism and Endocrinology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Min WangMetabolic Syndrome Research Center, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Ting XiaoMetabolic Syndrome Research Center, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China Key Laboratory of Diabetes Immunology, Ministry of Education, Institute of Metabolism and Endocrinology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Bangqi YinMetabolic Syndrome Research Center, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Linyun HeMetabolic Syndrome Research Center, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China Key Laboratory of Diabetes Immunology, Ministry of Education, Institute of Metabolism and Endocrinology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Wen MengMetabolic Syndrome Research Center, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Meijuan DongMetabolic Syndrome Research Center, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China Key Laboratory of Diabetes Immunology, Ministry of Education, Institute of Metabolism and Endocrinology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Feng LiuMetabolic Syndrome Research Center, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China Key Laboratory of Diabetes Immunology, Ministry of Education, Institute of Metabolism and Endocrinology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China Department of Pharmacology, University of Texas Health Science Center, San Antonio, TX liuf@uthscsa.edu.
Central South University · CNSecond Xiangya Hospital of Central South University · CN

Funding

Regulation and Function of Adiponectin OligomerizationR01DK076902 · NIDDK · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI LIU, FENG · 2008 to 2017
$2.9M
NIDDK NIH HHS R01 DK076902
6 · The paper itself

Abstract

Members of the microRNA (miR)-30 family have been reported to promote adipogenesis and inhibit osteogenesis, yet their role in the regulation of thermogenesis remains unknown. In this study, we show that miR-30b/c concentrations are greatly increased during adipocyte differentiation and are stimulated by cold exposure or the β-adrenergic receptor activator. Overexpression and knockdown of miR-30b and -30c induced and suppressed, respectively, the expression of thermogenic genes such as UCP1 and Cidea in brown adipocytes. Forced expression of miR-30b/c also significantly increased thermogenic gene expression and mitochondrial respiration in primary adipocytes derived from subcutaneous white adipose tissue, demonstrating a promoting effect of miRNAs on the development of beige fat. In addition, knockdown of miR-30b/c repressed UCP1 expression in brown adipose tissue in vivo. miR-30b/c targets the 3'-untranslated region of the receptor-interacting protein 140 (RIP140), and overexpression of miR-30b/c significantly reduced RIP140 expression. Consistent with RIP140 as a target of miR-30b/c in regulating thermogenic gene expression, overexpression of RIP140 greatly suppressed the promoting effect of miR-30b/c on the expression of UCP1 and Cidea in brown adipocytes. Taken together, the data from our study identify miR-30b/c as a key regulator of thermogenesis and uncover a new mechanism underlying the regulation of brown adipose tissue function and the development of beige fat.

Indexed as

Adaptor Proteins, Signal TransducingAdipocytes, BrownAnimalsBlotting, WesternCell DifferentiationCold TemperatureMaleMiceMice, Inbred C57BLMicroRNAsNuclear ProteinsNuclear Receptor Interacting Protein 1ThermogenesisAdaptor Proteins, Signal TransducingMicroRNAsMirn30d microRNA, mouseNuclear ProteinsNuclear Receptor Interacting Protein 1

Identifiers

PMID25576051
PMCPMC4876748
OpenAlexW2161305906

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.