ArticleOsteoarthritis and cartilage2015
The relation of MRI-detected structural damage in the medial and lateral patellofemoral joint to knee pain: the Multicenter and Framingham Osteoarthritis Studies.
Article in Osteoarthritis and cartilage, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03446404 (Standing Computerized Tomography), which is not on this map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Standing Computerized Tomography (SCT) Imaging of the Knee Joint in People With or at Risk for Knee Osteoarthritis (KOA)
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- A systematic review of the relationship between subchondral bone features, pain and structural pathology in peripheral joint osteoarthritis.Arthritis research & therapy · 2015Pooled it
- 3-D landmarking repeatability emphasizes challenges in scan positioning during weight bearing CT of the knee.Osteoarthritis imaging · 2026Article
- Knee Osteoarthritis on MRI in Symptomatic Young Adults After ACL Reconstruction From the SUPER-Knee Trial: Feature Prevalence and Association With Early-Stage Clinical Osteoarthritis Criteria.Orthopaedic journal of sports medicine · 2026Article
- MRI-Histopathology Correlation of Cartilage and Bone in Early Knee Osteoarthritis.Journal of orthopaedic case reports · 2025Article
- Association between progression of knee osteoarthritis pathology and gait changes over two years: Data from the IMI-APPROACH cohort.Osteoarthritis imaging · 2024Article
- Magnetic resonance imaging for assessment of the quadriceps tendon cross-sectional area as an adjunctive diagnostic parameter in patients with patellofemoral pain syndrome.Joint diseases and related surgery · 2023Article
- Relation of MRI-Detected Features of Patellofemoral Osteoarthritis to Pain, Performance-Based Function, and Daily Walking: The Multicenter Osteoarthritis Study.ACR open rheumatology · 2022Article
- Ultrasound investigation into the relationship between hip adduction and the patellofemoral joint.Journal of physical therapy science · 2021Article
- Increased femoral antetorsion correlates with higher degrees of lateral retropatellar cartilage degeneration, further accentuated in genu valgum.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2021Article
- Psychological and Pain Sensitization Characteristics Are Associated With Patellofemoral Osteoarthritis Symptoms: The Multicenter Osteoarthritis Study.The Journal of rheumatology · 2020Article
- Injectable Amniotic Membrane/Umbilical Cord Particulate for Knee Osteoarthritis: A Prospective, Single-Center Pilot Study.Pain medicine (Malden, Mass.) · 2019Article
- The association of frontal plane alignment to MRI-defined worsening of patellofemoral osteoarthritis: the MOST study.Osteoarthritis and cartilage · 2019Article
- Relation of meniscus pathology to prevalence and worsening of patellofemoral joint osteoarthritis: the Multicenter Osteoarthritis Study.Osteoarthritis and cartilage · 2018Article
- Local associations between knee cartilage TThe Knee · 2018Article
- Hyperintense signal alteration in the suprapatellar fat pad on MRI is associated with degeneration of the patellofemoral joint over 48 months: data from the Osteoarthritis Initiative.Skeletal radiology · 2018Article
- Patellofemoral morphology and alignment: reference values and dose-response patterns for the relation to MRI features of patellofemoral osteoarthritis.Osteoarthritis and cartilage · 2017Article
- Clinical Significance of Medial Versus Lateral Compartment Patellofemoral Osteoarthritis: Cross-Sectional Analyses in an Adult Population With Knee Pain.Arthritis care & research · 2017Observational
- Changes in clinical symptoms and functional disability in patients with coexisting patellofemoral and tibiofemoral osteoarthritis: a 1-year prospective cohort study.BMC musculoskeletal disorders · 2017Article
- Patellofemoral pain in athletes.Open access journal of sports medicine · 2017Review
- Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 2 countries.
Funding
Abstract
objectiveTo examine the relation of cartilage loss and bone marrow lesions (BMLs) in the medial and lateral patellofemoral joint (PFJ) to knee pain.
methodsWe categorized the location of full-thickness cartilage loss and BMLs in the PFJ on knee magnetic resonance imaging (MRIs) from the Multicenter Osteoarthritis (MOST) and Framingham Osteoarthritis (FOA) Studies as no damage, isolated medial, isolated lateral, or both medial and lateral (mixed). We determined the relation of MRI lesions in each PFJ region to prevalent knee pain. Differences in knee pain severity were compared among categories of PFJ full-thickness cartilage loss and BMLs using quantile regression.
resultsIn MOST (n = 1137 knees), compared with knees without full-thickness cartilage loss, knees with isolated lateral or mixed PFJ full-thickness cartilage loss had 1.9 (1.3, 2.8) and 1.9 (1.2, 2.9) times the odds of knee pain, respectively, while isolated medial cartilage loss had no association with knee pain. BMLs in both the medial and lateral PFJ had 1.5 (1.1, 2.0) times the odds of knee pain compared with knees without BMLs. Knee pain severity was lowest in knees with isolated medial PFJ cartilage loss or BMLs. In FOA (n = 934 knees), neither isolated medial nor lateral cartilage loss was associated with knee pain, whereas isolated BMLs in either region were associated with pain.
conclusionsResults were not completely concordant but suggest that knee pain risk and severity is greatest with cartilage loss isolated to (MOST) or inclusive of (MOST and FOA) the lateral PFJ. While BMLs in either the medial or lateral PFJ are related to pain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.