ArticleBMC medicine2015
The Hundred Person Wellness Project and Google's Baseline Study: medical revolution or unnecessary and potentially harmful over-testing?
Article in BMC medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- Short-term costs of integrating whole-genome sequencing into primary care and cardiology settings: a pilot randomized trial.Genetics in medicine : official journal of the American College of Medical Genetics · 2018Trial
- Association of 152 Biomarker Reference Intervals with All-Cause Mortality in Participants of a General United States Survey from 1999 to 2010.Clinical chemistry · 2021Article
- Precision Population Medicine in Primary Care: The Sanford Chip Experience.Frontiers in genetics · 2021Article
- Biomarker Application for Precision Medicine in Stroke.Translational stroke research · 2020Review
- Translational Metabolomics: Current Challenges and Future Opportunities.Metabolites · 2019Article
- Precision medicine in the clouds.Nature biotechnology · 2018Article
- Translational bioinformatics in the era of real-time biomedical, health care and wellness data streams.Briefings in bioinformatics · 2017Article
- The new holism: P4 systems medicine and the medicalization of health and life itself.Medicine, health care, and philosophy · 2016Article
- Personal Genome Sequencing in Ostensibly Healthy Individuals and the PeopleSeq Consortium.Journal of personalized medicine · 2016Review
- Assessing the Costs and Cost-Effectiveness of Genomic Sequencing.Journal of personalized medicine · 2015Review
- Human phenotyping on a population scale.Nature methods · 2015Article
- 2015, big data in healthcare: for whom the bell tolls?Critical care (London, England) · 2015Article
- Integrating big data and actionable health coaching to optimize wellness.BMC medicine · 2015Article
Corrections and comments
- Commented on by
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Hundred Person Wellness Project is an ambitious pilot undertaking, which aims to intensely monitor 100 individuals over 10 months. Patients with abnormal findings will be treated, in hopes that this early intervention will avoid, or delay, symptomatic disease. Google's "Baseline Study" is of similar scope and will enroll 10,000 people over 2 to 3 years. I here speculate that these approaches will likely not be effective in preventing disease, but instead, lead to unnecessary and potentially harmful interventions. Examples from the cancer screening experience over the last 30 years are provided, which show that intensive testing may uncover indolent disease or incidental findings which, when treated, may cause more harm than good. Additional examples show that aggressive treatments for cancer and other diseases do not always lead to better patient outcomes. I conclude that the recent advances in omics provide us with unprecedented opportunities for high content clinical testing, but such testing should be used with caution to avoid the harmful consequences of over-diagnosis and over-treatment. Despite the detailed rebuttals by Hood and colleagues in another commentary in BMC Medicine, time will show the actual benefits and harms of these ambitious initiatives.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.