Evidence map›Paper›PMID 25575795›Full record

ArticleNeuroscience letters2015

Activation of cannabinoid receptor 1 inhibits increased bladder activity induced by nerve growth factor.

Zun-Yi Wang, Peiqing Wang, Dale E Bjorling

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroscience letters, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Potential of Endocannabinoids to Control Bladder Pain.Frontiers in systems neuroscience · 2018
    Review
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Zun-Yi WangDepartments of Surgical Sciences, University of Wisconsin, Madison, WI, USA. Electronic address: wangz@svm.vetmed.wisc.edu.
Peiqing WangDepartments of Surgical Sciences, University of Wisconsin, Madison, WI, USA.
Dale E BjorlingDepartments of Surgical Sciences, University of Wisconsin, Madison, WI, USA; Departments of Urology, University of Wisconsin, Madison, WI, USA. Electronic address: bjorling@svm.vetmed.wisc.edu.
University of Wisconsin–Madison · US

Funding

Neurovascular and Behavorial Response to CystitisR01DK066349 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI BJORLING, DALE EDMOND · 2003 to 2010
$1.6M
Endogenous Cannabinoids and NGF Signaling in Pain Associated with CystitisR01DK088806 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI BJORLING, DALE EDMOND · 2010 to 2013
$1.3M
NIDDK NIH HHS DK R01 088806NIDDK NIH HHS R01 DK066349NIDDK NIH HHS R01 DK088806
6 · The paper itself

Abstract

Nerve growth factor (NGF) is an important mediator of inflammatory pain, in part by sensitizing afferent nerve fibers, and expression of NGF is increased during bladder inflammation. We investigated whether intravesical instillation of the selective cannabinoid receptor 1 (CB1) agonist arachidonyl-2'-chloroethylamide (ACEA) affects NGF-induced increased bladder activity in female C57BL/6J wild-type (WT) mice. We also examined the effects of intravesical NGF in female fatty acid amide hydrolase knock-out (FAAH KO) mice. We found that CB1 and tyrosine kinase A (trkA, the high-affinity NGF receptor) were present in L6 dorsal root ganglion (DRG) afferent neurons and in bladders of both genotypes. Intravesical NGF increased bladder activity that was inhibited by intravesical ACEA in WT mice. The inhibitory effects of ACEA were reversed by the selective CB1 antagonist AM 251. Intravesical NGF failed to affect bladder activity in FAAH KO mice, and treatment with AM251, restored the stimulatory effects of NGF on the bladder in FAAH KO mice. These results indicate that activation of CB1 inhibits increased bladder activity induced by NGF.

Indexed as

AmidohydrolasesAnimalsArachidonic AcidsFatty Acid Amide HydrolasesFemaleGanglia, SpinalMice, Inbred C57BLMice, KnockoutNerve Growth FactorNeurons, AfferentReceptor, Cannabinoid, CB1Receptor, trkAUrinary BladderAmidohydrolasesArachidonic Acidsarachidonyl-2-chloroethanolamideFatty Acid Amide HydrolasesNerve Growth FactorReceptor, Cannabinoid, CB1Receptor, trkABladderCannabinoid receptor 1Fatty acid amide hydrolaseMiceNerve growth factorTyrosine kinase A

Identifiers

PMID25575795
PMCPMC4339033
OpenAlexW2033033001

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.