ArticleMolecular brain2015
High expression of long intervening non-coding RNA OLMALINC in the human cortical white matter is associated with regulation of oligodendrocyte maturation.
Article in Molecular brain, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 34 citations in OpenAlex.
- Scanning transcriptomes for nonlinear, domain-level similarities using hmSEEKR.bioRxiv : the preprint server for biology · 2026Article
- Epigenetic regulation in cancer metastasis.Discover oncology · 2026Review
- The lncRNA MYRACL regulates human oligodendrocyte maturation and myelination.Molecular therapy : the journal of the American Society of Gene Therapy · 2025Article
- Non-Coding RNAs in the Regulation of Hippocampal Neurogenesis and Potential Treatment Targets for Related Disorders.Biomolecules · 2022Review
- Bioinformatics analysis of lncRNAs in the occurrence and development of osteosarcoma.Translational pediatrics · 2022Article
- Construction of an Immune-Related lncRNA Signature That Predicts Prognosis and Immune Microenvironment in Osteosarcoma Patients.Frontiers in oncology · 2022Article
- Decoding LncRNAs.Cancers · 2021Review
- The Role of the lncRNA-LRCF in Propofol-Induced Oligodendrocyte Damage in Neonatal Mouse.Neurochemical research · 2021Article
- Functionally Enigmatic Genes in Cancer: Using TCGA Data to Map the Limitations of Annotations.Scientific reports · 2020Article
- The functions of long non-coding RNAs in neural stem cell proliferation and differentiation.Cell & bioscience · 2020Review
- Novel Lipid Long Intervening Noncoding RNA, Oligodendrocyte Maturation-Associated Long Intergenic Noncoding RNA, Regulates the Liver Steatosis Gene Stearoyl-Coenzyme A Desaturase As an Enhancer RNA.Hepatology communications · 2019Article
- Conserved temporal ordering of promoter activation implicates common mechanisms governing the immediate early response across cell types and stimuli.Open biology · 2018Article
- Long Non-coding RNAs as Local Regulators of Pancreatic Islet Transcription Factor Genes.Frontiers in genetics · 2018Review
- Transcriptional regulation of long-term potentiation.Neurogenetics · 2016Review
- Epigenetic control of oligodendrocyte development: adding new players to old keepers.Current opinion in neurobiology · 2016Review
- LINC00507 Is Specifically Expressed in the Primate Cortex and Has Age-Dependent Expression Patterns.Journal of molecular neuroscience : MN · 2016Article
- The Antisense Transcriptome and the Human Brain.Journal of molecular neuroscience : MN · 2016Review
- Long intervening non-coding RNA 00320 is human brain-specific and highly expressed in the cortical white matter.Neurogenetics · 2015Article
- Conservation and tissue-specific transcription patterns of long noncoding RNAs.Journal of human transcriptome · 2015Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundLong intervening non-coding RNAs (lincRNAs) are a recently discovered subclass of non-coding RNAs. LincRNAs are expressed across the mammalian genome and contribute to the pervasive transcription phenomenon. They display a tissue-specific and species-specific mode of expression and are present abundantly in the brain.
resultsHere, we report the expression patterns of oligodendrocyte maturation-associated long intervening non-coding RNA (OLMALINC), which is highly expressed in the white matter (WM) of the human frontal cortex compared to the grey matter (GM) and peripheral tissues. Moreover, we identified a novel isoform of OLMALINC that was also up-regulated in the WM. RNA-interference (RNAi) knockdown of OLMALINC in oligodendrocytes, which are the major cell type in the WM, caused significant changes in the expression of genes regulating cytostructure, cell activation and membrane signaling. Gene ontology enrichment analysis revealed that over 10% of the top 25 up- and down-regulated genes were involved in oligodendrocyte maturation. RNAi experiments in neuronal cells resulted in the perturbation of genes controlling cell proliferation. Furthermore, we identified a novel cis-natural antisense non-coding RNA, which we named OLMALINC-AS, which maps to the first exon of the dominant isoform of OLMALINC.
conclusionsOur study has demonstrated for the first time that a primate-specific lincRNA regulates the expression of genes critical to human oligodendrocyte maturation, which in turn might be regulated by an antisense counterpart.
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