ReviewCellular and molecular life sciences : CMLS2015
c-kit(+) cells: the tell-tale heart of cardiac regeneration?
Review in Cellular and molecular life sciences : CMLS, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 20 citations in OpenAlex.
- Review
- Heterogeneity of adult masseter muscle satellite cells with cardiomyocyte differentiation potential.Experimental cell research · 2018Article
- Cardiac c-Kit Biology Revealed by Inducible Transgenesis.Circulation research · 2018Article
- Identity Crisis for Regenerative Cardiac cKitCirculation research · 2017Review
- Platelet Derived Growth Factor Alpha (PDGFRα) Induces the Activation of Cardiac Fibroblasts by Activating c-Kit.Medical science monitor : international medical journal of experimental and clinical research · 2017Article
- Sildenafil attenuates hypoxic pulmonary remodelling by inhibiting bone marrow progenitor cells.Journal of cellular and molecular medicine · 2017Article
- miR-21 increases c-kitPeerJ · 2017Article
- Acute Catecholamine Exposure Causes Reversible Myocyte Injury Without Cardiac Regeneration.Circulation research · 2016Article
- Hiding inside? Intracellular expression of non-glycosylated c-kit protein in cardiac progenitor cells.Stem cell research · 2016Article
- miR-21 Reduces Hydrogen Peroxide-Induced Apoptosis in c-kitOxidative medicine and cellular longevity · 2016Article
- Translational aspects of cardiac cell therapy.Journal of cellular and molecular medicine · 2015Review
- Cardiac aging - Getting to the stem of the problem.Journal of molecular and cellular cardiology · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cardiovascular disease is the leading cause of morbidity and mortality in the developed world. Although ongoing therapeutic strategies ameliorate symptoms and prolong life for patients with cardiovascular diseases, they do not solve the critical issue related to the loss of cardiac tissue. Accordingly, stem/progenitor cell therapy has emerged as a paramount approach for cardiac repair and regeneration. In this regard, c-kit(+) cells have animated much interest and controversy. These cells are self-renewing, clonogenic, and multipotent and display a noteworthy potential to differentiate into all cardiovascular lineages. However, their functional contribution to cardiomyocyte turnover is one of the centrally debated issues concerning their regenerative potential. Regardless, plentiful preclinical and clinical studies have been conducted which provide evidence for the capacity of c-kit(+) cells to improve cardiac function. The purpose of this review is to give a comprehensive, impartial, critical description and evaluation of the literature on c-kit(+) cells from bench to bedside in order to address their true potential, benefits and controversies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.