Evidence map›Paper›PMID 25575465›Full record

ArticleTrends in immunology2015

Environmentally-defined enhancer populations regulate diversity of tissue-resident macrophages.

Michael Bulger, James Palis

Abstract readComment
In one paragraph

Article in Trends in immunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Michael BulgerCenter for Pediatric Biomedical Research, Department of Pediatrics, University of Rochester, Rochester, NY, USA. Electronic address: michael_bulger@urmc.rochester.edu.
James PalisCenter for Pediatric Biomedical Research, Department of Pediatrics, University of Rochester, Rochester, NY, USA.

Funding

The University of Rochester's Clinical and Translational Science InstituteUL1TR000042 · NCATS · UNIVERSITY OF ROCHESTER · PI BENNETT, NANCY M, KIEBURTZ, KARL D. · 2012 to 2015
$14.4M
Function of active chromatin domains in erythropoiesisR01DK070687 · NIDDK · UNIVERSITY OF ROCHESTER · PI BULGER, MICHAEL D · 2007 to 2016
$2.5M
Ontogeny of erythroid lineage differentiationR01DK071116 · NIDDK · UNIVERSITY OF ROCHESTER · PI PALIS, JAMES · 2006 to 2010
$2.2M
Initiation of Mammalian Embryonic HematopoiesisR01DK079361 · NIDDK · UNIVERSITY OF ROCHESTER · PI PALIS, JAMES · 2007 to 2012
$1.5M
NIDDK NIH HHS R01 DK070687NIDDK NIH HHS R01 DK071116NIDDK NIH HHS R01 DK079361
6 · The paper itself

Abstract

Macrophages represent a class of cells specialized for phagocytosis that occurs in multiple, phenotypically distinct populations throughout the body. Two studies published in Cell demonstrate that these phenotypic differences reflect drastic differences in the populations of enhancers that regulate transcription, and that this epigenomic diversity is, in fact, highly plastic and sensitive to environmental cues.

Indexed as

Enhancer Elements, GeneticEpigenesis, GeneticAnimalsFemaleHistonesMacrophagesMaleHistonescellular plasticityenhancershistone modificationmacrophagestranscription factors

Identifiers

PMID25575465
PMCPMC4322767

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.