ArticleAnnals of surgery2015
Bile Routing Modification Reproduces Key Features of Gastric Bypass in Rat.
Article in Annals of surgery, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Metabolomic signatures after bariatric surgery - a systematic review.Reviews in endocrine & metabolic disorders · 2022Pooled it
- The Influence of Bariatric Surgery on Serum Bile Acids in Humans and Potential Metabolic and Hormonal Implications: a Systematic Review.Current obesity reports · 2015Pooled it
- The effect of metabolic surgery on type 1 diabetes: meta-analysis.Archives of endocrinology and metabolismPooled it
- Early diabetes-like phenotypes in germ-free mice induced by gut microbiota from patients with type 2 diabetes.Animal models and experimental medicine · 2026Article
- Long-Term Outcome of Isolated Duodenal Transit Bipartition as Initial Metabolic Surgery: A 19-Year Follow-Up Case Report.The American journal of case reports · 2026Article
- Farnesoid X receptor is inhibited after ileum transposition in diabetic rats: its hypoglycemic effect.International journal of medical sciences · 2023Article
- Duodenal-jejunal bypass reduces serum ceramidesWorld journal of gastroenterology · 2022Article
- Sodium-glucose co-transporter 1 (SGLT1) differentially regulates gluconeogenesis and GLP-1 receptor (GLP-1R) expression in different diabetic rats: a preliminary validation of the hypothesis of "SGLT1 bridge" as an indication for "surgical diabetes".Annals of translational medicine · 2022Article
- Metabolic benefits of gastric bypass surgery in the mouse: The role of fecal losses.Molecular metabolism · 2020Article
- Bile acid changes after metabolic surgery are linked to improvement in insulin sensitivity.The British journal of surgery · 2019Observational
- Additional effects of duodenojejunal bypass on glucose metabolism in a rat model of sleeve gastrectomy.Surgery today · 2019Article
- Bile Diversion Improves Metabolic Phenotype Dependent on Farnesoid X Receptor (FXR).Obesity (Silver Spring, Md.) · 2019Article
- Role of Bile Acids in Bariatric Surgery.Frontiers in physiology · 2019Review
- Increased Bile Acid Signals After Duodenal-Jejunal Bypass Improve Non-alcoholic Steatohepatitis (NASH) in a Rodent Model of Diet-Induced NASH.Obesity surgery · 2018Article
- Metabolic Effect of Foregut Exclusion Demonstrated by the Impact of Gastrogastric Fistula on Recurrence of Diabetes.Journal of the American College of Surgeons · 2018Article
- Bile acids in glucose metabolism in health and disease.The Journal of experimental medicine · 2018 · on this mapReview
- Bile acids and bariatric surgery.Molecular aspects of medicine · 2017Review
- Gut microbial degradation of organophosphate insecticides-induces glucose intolerance via gluconeogenesis.Genome biology · 2017Article
- Influence of Roux-en-Y gastric bypass on plasma bile acid profiles: a comparative study between rats, pigs and humans.International journal of obesity (2005) · 2016Article
- Activation of bile acid signaling improves metabolic phenotypes in high-fat diet-induced obese mice.American journal of physiology. Gastrointestinal and liver physiology · 2016Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the role of bile routing modification on the beneficial effects of gastric bypass surgery on glucose and energy metabolism.
backgroundGastric bypass surgery (GBP) promotes early improvements in glucose and energy homeostasis in obese diabetic patients. A suggested mechanism associates a decrease in hepatic glucose production to an enhanced intestinal gluconeogenesis. Moreover, plasma bile acids are elevated after GBP and bile acids are inhibitors of gluconeogenesis.
methodsIn male Sprague-Dawley rats, we performed bile diversions from the bile duct to the midjejunum or the mid-ileum to match the modified bile delivery in the gut occurring in GBP. Body weight, food intake, glucose tolerance, insulin sensitivity, and food preference were analyzed. The expression of gluconeogenesis genes was evaluated in both the liver and the intestine.
resultsBile diversions mimicking GBP promote an increase in plasma bile acids and a marked improvement in glucose control. Bile bioavailability modification is causal because a bile acid sequestrant suppresses the beneficial effects of bile diversions on glucose control. In agreement with the inhibitory role of bile acids on gluconeogenesis, bile diversions promote a blunting in hepatic glucose production, whereas intestinal gluconeogenesis is increased in the gut segments devoid of bile. In rats fed a high-fat-high-sucrose diet, bile diversions improve glucose control and dramatically decrease food intake because of an acquired disinterest in fatty food.
conclusionsThis study shows that bile routing modification is a key mechanistic feature in the beneficial outcomes of GBP.
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