Trial reportAnnals of surgery2015
Minimally invasive esophagectomy: results of a prospective phase II multicenter trial-the eastern cooperative oncology group (E2202) study.
Trial report in Annals of surgery, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05105945 (A Randomized, Controlled, Multi-center Clinical Study on the Efficacy of Single-port Inflatable Mediastinoscopy Combined With Laparoscopic-assisted Small Incision Surgery and Thoracoscopy Combined With Laparoscopic Surgery for Radical Esophagectomy), which is not on this map. Cited by 86 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Randomized, Controlled, Multi-center Clinical Study on the Efficacy of Single-port Inflatable Mediastinoscopy Combined With Laparoscopic-assisted Small Incision Surgery and Thoracoscopy Combined With Laparoscopic Surgery for Radical Esophagectomy
Who cites it
86 citing papers in PubMed, 4 syntheses or guidelines pooled it, 207 citations in OpenAlex.
- A Systematic Mapping Review of Core Outcome Reporting in Surgical Research for Oesophageal Cancer.Journal of surgical oncology · 2026Pooled it
- Novel Mediastinoscope-Assisted Minimally Invasive Esophagectomy for Esophageal Cancer: A Systematic Review and Meta-analysis.Annals of surgical oncology · 2023Pooled it
- Enhanced recovery pathways vs standard care pathways in esophageal cancer surgery: systematic review and meta-analysis.Esophagus : official journal of the Japan Esophageal Society · 2020Pooled it
- Minimally invasive esophagectomy performed with the patient in a prone position: a systematic review.Surgery today · 2016Pooled it
- Early Oral Feeding Following McKeown Minimally Invasive Esophagectomy: An Open-label, Randomized, Controlled, Noninferiority Trial.Annals of surgery · 2018Trial
- Evaluation of safety profile of thoracoscopic esophagectomy for T1bN0M0 cancer using data from JCOG0502: a prospective multicenter study.Surgical endoscopy · 2015Trial
- Thoracoscopic phase with mini-thoracotomy during laparoscopic Ivor Lewis esophagectomy is associated with a reduced risk of postoperative acute respiratory distress syndrome.Updates in surgery · 2026Article
- Evolution and refinements in minimally invasive esophagectomy: a narrative review.Journal of thoracic disease · 2026Review
- How to Define the Gastroesophageal Junction.Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society · 2026Review
- Comparative outcomes of laparoscopic versus robotic esophagectomy: a systematic review and meta-analysis.Kardiochirurgia i torakochirurgia polska = Polish journal of cardio-thoracic surgery · 2025Review
- Initial experience of complete portal robotic esophagectomy for esophageal carcinoma in semi-prone position under single-lumen insertion for anaesthesia.Journal of thoracic disease · 2025Article
- Survival comparison between open and thoracoscopic esophagectomy for node-negative esophageal squamous cell cancer: an ambispective cohort study.Surgical endoscopy · 2024Article
- Current status and prospects of diagnosis and treatment for esophageal cancer with supraclavicular lymph node metastasis.Frontiers in oncology · 2024Review
- Article
- Major Intraoperative Complications During Minimally Invasive Esophagectomy.Annals of surgical oncology · 2023Article
- Incidence and Impact of Preoperative Hiatal Hernia in Patients with Esophageal Carcinoma Undergoing Curative Surgical Resection.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2023Article
- Evolving Perspectives on Esophagectomy Care: Clinical Update.Anesthesiology · 2023Article
- Different gastric tubes in esophageal reconstruction during esophagectomy.Esophagus : official journal of the Japan Esophageal Society · 2023Review
- Perioperative therapy landscape for locally advanced, resectable esophageal cancer: an updated literature review.Journal of thoracic disease · 2023Review
- Consequences of anastomotic leaks after minimally invasive esophagectomy: A single-center experience.Surgery open science · 2023Article
26 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
11 authors at 7 institutions in 1 country.
Funding
Abstract
objectiveThe primary aim of this trial was to assess the feasibility of minimally invasive esophagectomy (MIE) in a multi-institutional setting.
backgroundEsophagectomy is an important, potentially curative treatment for localized esophageal cancer, but is a complex operation. MIE may decrease the morbidity and mortality of resection, and single-institution studies have demonstrated successful outcomes with MIE.
methodsWe conducted a multicenter, phase II, prospective, cooperative group study (coordinated by the Eastern Cooperative Oncology Group) to evaluate the feasibility of MIE. Patients with biopsy-proven high-grade dysplasia or esophageal cancer were enrolled at 17 credentialed sites. Protocol surgery consisted of either 3-stage MIE or Ivor Lewis MIE. The primary end point was 30-day mortality. Secondary end points included adverse events, duration of hospital-stay, and 3-year outcomes.
resultsProtocol surgery was completed in 95 of the 104 patients eligible for the primary analysis (91.3%). The 30-day mortality in eligible patients who underwent MIE was 2.1%; perioperative mortality in all registered patients eligible for primary analysis was 2.9%. Median intensive care unit and hospital stay were 2 and 9 days, respectively. Grade 3 or higher adverse events included anastomotic leak (8.6%), acute respiratory distress syndrome (5.7%), pneumonitis (3.8%), and atrial fibrillation (2.9%). At a median follow-up of 35.8 months, the estimated 3-year overall survival was 58.4% (95% confidence interval: 47.7%-67.6%). Locoregional recurrence occurred in only 7 patients (6.7%).
conclusionsThis prospective multicenter study demonstrated that MIE is feasible and safe with low perioperative morbidity and mortality and good oncological results. This approach can be adopted by other centers with appropriate expertise in open esophagectomy and minimally invasive surgery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.