Evidence map›Paper›PMID 25575134›Full record

ArticleJournal of neuropathology and experimental neurology2015

Notch signaling activation in pediatric low-grade astrocytoma.

William D Brandt, Karisa C Schreck, Eli E Bar, Isabella Taylor, Luigi Marchionni, Eric Raabe, Charles G Eberhart, Fausto J Rodriguez

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuropathology and experimental neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

William D BrandtFrom the Departments of Pathology (WDB, KCS, IT, ER, CGE, FJR), Neuroscience (KCS, EEB), and Oncology (LM, ER, CGE, FJR), Johns Hopkins University, Baltimore, Maryland; and Department of Neurological Surgery, Case Western Reserve University, Cleveland, Ohio (EEB).
Karisa C Schreck
Eli E Bar
Isabella Taylor
Luigi Marchionni
Eric Raabe
Charles G Eberhart
Fausto J Rodriguez
Johns Hopkins University · US

Funding

Translational Research Central ServicesP30CA006973 · NCI · JOHNS HOPKINS UNIVERSITY · PI WILLIAM George NELSON · 1985 to 2026
$208.6M
Notch signaling in brain tumorsR01NS055089 · NINDS · JOHNS HOPKINS UNIVERSITY · PI EBERHART, CHARLES G · 2007 to 2016
$3.2M
NCI NIH HHS P30 CA006973NCI NIH HHS P30CA006973NINDS NIH HHS R01 NS055089NINDS NIH HHS R01NS055089
6 · The paper itself

Abstract

Pilocytic astrocytoma (PA) is the most common primary brain tumor in children; various signaling pathways have been implicated in its biology. The Notch signaling pathway has been found to play a role in the development, stem cell biology, and pathogenesis of several cancers, but its role in PA has not been investigated. We studied alterations in Notch signaling components in tumor tissue from 18 patients with PA and 4 with other low-grade astrocytomas to identify much needed therapeutic targets. We found that Notch pathway members were overexpressed at the mRNA (NOTCH1, NOTCH2, HEY1, HEY2) and protein (HES1) levels in PAs at various anatomic sites compared with non-neoplastic brain samples. These changes were not associated with specific BRAF alterations. Inhibiting the Notch pathway in the pediatric low-grade astrocytoma cell lines Res186 and Res259 using either RNA interference or a γ-secretase inhibitor resulted in variable, but significant, reduction in cell growth and migration. This study suggests a potential role for Notch signaling in pediatric low-grade astrocytoma tumorigenesis and that Notch signaling may be a viable pathway therapeutic target.

Indexed as

AdolescentAntineoplastic AgentsAstrocytomaBasic Helix-Loop-Helix ProteinsBrain NeoplasmsCell Line, TumorCell MovementCell ProliferationChildChild, PreschoolCore Binding FactorsCyclic S-OxidesEnzyme InhibitorsFemaleGene Expression Regulation, NeoplasticHomeodomain ProteinsAntineoplastic AgentsBasic Helix-Loop-Helix ProteinsCore Binding FactorsCyclic S-OxidesEnzyme InhibitorsHES1 protein, humanHomeodomain ProteinsImmunoglobulin J Recombination Signal Sequence-Binding ProteinMRK 003RBPJ protein, humanReceptors, NotchThiadiazolesTranscription Factor HES-1

Identifiers

PMID25575134
PMCPMC4357229
OpenAlexW2093037174

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.