ArticlePloS one2015
Correlation of the apparent diffusion coefficient (ADC) with the standardized uptake value (SUV) in lymph node metastases of non-small cell lung cancer (NSCLC) patients using hybrid 18F-FDG PET/MRI.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Meta-Analysis of the Correlation between Apparent Diffusion Coefficient and Standardized Uptake Value in Malignant Disease.Contrast media & molecular imaging · 2017Pooled it
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- [Progress in Image-planned and Real-time Image-guided Lung Cancer Biopsy in the Detection of Biomarkers].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2023Review
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- Molecular Imaging of Pulmonary Inflammation and Infection.International journal of molecular sciences · 2020Review
- Can integrated 18F-FDG PET/MR replace sentinel lymph node resection in malignant melanoma?European journal of nuclear medicine and molecular imaging · 2018Article
- Diffusion-weighted MRI and PET-CT in the follow up of chronic periaortitis.The international journal of cardiovascular imaging · 2018Article
- Prediction of pathological nodal involvement by CT-based Radiomic features of the primary tumor in patients with clinically node-negative peripheral lung adenocarcinomas.Medical physics · 2018Article
- Multiparametric FDG-PET/MRI of Hepatocellular Carcinoma: Initial Experience.Contrast media & molecular imaging · 2018Article
- Metabolic Volumetric Parameters inContrast media & molecular imaging · 2018Article
- Biomarkers from in vivo molecular imaging of breast cancer: pretreatmentMagma (New York, N.Y.) · 2017Article
- FDG Whole-Body PET/MRI in Oncology: a Systematic Review.Nuclear medicine and molecular imaging · 2017Review
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- Clinical PET-MR Imaging in Breast Cancer and Lung Cancer.PET clinics · 2016Review
- PET/MRI in pancreatic and periampullary cancer: correlating diffusion-weighted imaging, MR spectroscopy and glucose metabolic activity with clinical stage and prognosis.European journal of nuclear medicine and molecular imaging · 2016Article
- Correlation of diffusion MRI with the Ki-67 index in non-small cell lung cancer.Radiology and oncology · 2015Article
- Magnetic resonance imaging for staging of non-small-cell lung cancer-technical advances and unmet needs.Journal of thoracic disease · 2015Article
- Article
Corrections and comments
- Erratum issuedCorrection: Correlation of the apparent diffusion coefficient (ADC) with the standardized uptake value (SUV) in lymph node metastases of non-small cell lung cancer (NSCLC) patients using hybrid 18F-FDG PET/MRI.2015 · Grueneien, Johannes [corrected to Grueneisen, Johannes]
- Erratum issued
Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo compare the apparent diffusion coefficient (ADC) in lymph node metastases of non-small cell lung cancer (NSCLC) patients with standardized uptake values (SUV) derived from combined 18F-fluoro-deoxy-glucose-positron emission tomography/magnetic resonance imaging (18F-FDG PET/MRI). MATERIAL AND
methods38 patients with histopathologically proven NSCLC (mean age 60.1 ± 9.5 y) received whole-body PET/CT (Siemens mCT™) 60 min after injection of a mean dose of 280 ± 50 MBq 18F-FDG and subsequent PET/MRI (mean time after tracer injection: 139 ± 26 min, Siemens Biograph mMR). During PET acquisition, simultaneous diffusion-weighted imaging (DWI, b values: 0, 500, 1000 s/mm²) was performed. A maximum of 10 lymph nodes per patient suspicious for malignancy were analyzed. Regions of interest (ROI) were drawn covering the entire lymph node on the attenuation-corrected PET-image and the monoexponential ADC-map. According to histopathology or radiological follow-up, lymph nodes were classified as benign or malignant. Pearson's correlation coefficients were calculated for all lymph node metastases correlating SUVmax and SUVmean with ADCmean.
resultsA total of 146 suspicious lymph nodes were found in 25 patients. One hundred lymph nodes were eligible for final analysis. Ninety-one lymph nodes were classified as malignant and 9 as benign according to the reference standard. In malignant lesions, mean SUVmax was 9.1 ± 3.8 and mean SUVmean was 6.0 ± 2.5 while mean ADCmean was 877.0 ± 128.6 x10(-5) mm²/s in PET/MRI. For all malignant lymph nodes, a weak, inverse correlation between SUVmax and ADCmean as well as SUVmean and ADCmean (r = -0.30, p<0.05 and r = -0.36, p<0.05) existed.
conclusionThe present data show a weak inverse correlation between increased glucose-metabolism and cellularity in lymph node metastases of NSCLC patients. 18F-FDG-PET and DWI thus may offer complementary information for the evaluation of treatment response in lymph node metastases of NSCLC.
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