ArticleMolecular cell2015
The Streptococcus mutans irvA gene encodes a trans-acting riboregulatory mRNA.
Article in Molecular cell, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 49 citations in OpenAlex.
- A small RNA fromVirulence · 2025Article
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- Illuminating the oral microbiome and its host interactions: tools and approaches for molecular ecological studies.FEMS microbiology reviews · 2023Review
- Glutamine synthetase mRNA releases sRNA from its 3'UTR to regulate carbon/nitrogen metabolic balance ineLife · 2022Article
- RNase III-CLASH of multi-drug resistant Staphylococcus aureus reveals a regulatory mRNA 3'UTR required for intermediate vancomycin resistance.Nature communications · 2022Article
- Causal Discovery in High-dimensional, Multicollinear Datasets.Frontiers in epidemiology · 2022Article
- Modulation ofFrontiers in genetics · 2022Article
- Small regulatory RNAs of oral streptococci and periodontal bacteria.The Japanese dental science review · 2021Review
- Article
- Regulatory control of the Streptococcus mutans HdrRM LytTR Regulatory System functions via a membrane sequestration mechanism.Molecular microbiology · 2020Article
- Environmental stress perception activates structural remodeling of extant Streptococcus mutans biofilms.NPJ biofilms and microbiomes · 2020Article
- An mRNA-mRNA Interaction Couples Expression of a Virulence Factor and Its Chaperone in Listeria monocytogenes.Cell reports · 2020Article
- Functional expansion of a TCA cycle operon mRNA by a 3' end-derived small RNA.Nucleic acids research · 2019Article
- Examining the Protein Interactome and Subcellular Localization of RNase J2 Complexes inFrontiers in microbiology · 2019Article
- Dual-Function RNAs.Microbiology spectrum · 2018Review
- RNases and Helicases in Gram-Positive Bacteria.Microbiology spectrum · 2018Article
- RNase Y-mediated regulation of the streptococcal pyrogenic exotoxin B.RNA biology · 2018Article
- Expression of BrpA in Streptococcus mutans is regulated by FNR-box mediated repression.Molecular oral microbiology · 2017Article
- Identification of small RNAs abundant in Burkholderia cenocepacia biofilms reveal putative regulators with a potential role in carbon and iron metabolism.Scientific reports · 2017Article
- sRNA-mediated activation of gene expression by inhibition of 5'-3' exonucleolytic mRNA degradation.eLife · 2017Article
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
In both prokaryotes and eukaryotes, insight into gene function is typically obtained by in silico homology searches and/or phenotypic analyses of strains bearing mutations within open reading frames. However, the studies herein illustrate how mRNA function is not limited to the expression of a cognate protein. We demonstrate that a stress-induced protein-encoding mRNA (irvA) from the dental caries pathogen Streptococcus mutans directly modulates target mRNA (gbpC) stability through seed pairing interactions. The 5' untranslated region of irvA mRNA is a trans riboregulator of gbpC and a critical activator of the DDAG stress response, whereas IrvA functions independently in the regulation of natural competence. The irvA riboregulatory domain controls GbpC production by forming irvA-gbpC hybrid mRNA duplexes that prevent gbpC degradation by an RNase J2-mediated pathway. These studies implicate a potentially ubiquitous role for typical protein-encoding mRNAs as riboregulators, which could alter current concepts in gene regulation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.