ArticleMarine drugs2015
Chitosan in mucoadhesive drug delivery: focus on local vaginal therapy.
Article in Marine drugs, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 62 citations in OpenAlex.
- Formulation, characterization and evaluation of cytotoxic potential for febuxostat loaded chitosomes against cervical cancer cells (Hela cells).Scientific reports · 2026Article
- Review
- Hydrogel adhesives for upper gastrointestinal wound healing.Theranostics · 2026Review
- Optimization and preparation of in-situ mucoadhesive gel of azithromycin hydroxypropyl-β-cyclodextrin inclusion complex against upper respiratory tract infections.BMC pharmacology & toxicology · 2025Article
- Encapsulation of Active Substances in Natural Polymer Coatings.Materials (Basel, Switzerland) · 2024Review
- Chimeric nanobody-decorated liposomes by self-assembly.Nature nanotechnology · 2024Article
- Chitosan-Coated SLN: A Potential System for Ocular Delivery of Metronidazole.Pharmaceutics · 2023Article
- Development of Ulvan-Containing Liposomes as Antibacterial Drug Delivery Platforms.Journal of functional biomaterials · 2022Article
- Preparation and Characterization of Chitosan-Alginate Microspheres Loaded with Quercetin.Polymers · 2022Article
- Chitosan-based delivery system enhances antimicrobial activity of chlorhexidine.Frontiers in microbiology · 2022Article
- Potential of mucoadhesive chitosan glutamate microparticles as microbicide carriers - antiherpes activity and penetration behavior across the human vaginal epithelium.Drug delivery · 2021Article
- Increasing the Power of Polyphenols through Nanoencapsulation for Adjuvant Therapy against Cardiovascular Diseases.Molecules (Basel, Switzerland) · 2021Review
- Chitosomes-In-Chitosan Hydrogel for Acute Skin Injuries: Prevention and Infection Control.Marine drugs · 2021Article
- A Bilayer Vaginal Tablet for the Localized Delivery of Disulfiram and 5-Fluorouracil to the Cervix.Pharmaceutics · 2020Article
- The Vaginal-PVPA: A Vaginal Mucosa-Mimicking In Vitro Permeation Tool for Evaluation of Mucoadhesive Formulations.Pharmaceutics · 2020Article
- The Antimicrobial Properties of Chitosan Can be Tailored by Formulation.Marine drugs · 2020Article
- Dapivirine Bioadhesive Vaginal Tablets Based on Natural Polymers for the Prevention of Sexual Transmission of HIV.Polymers · 2019Article
- Chitosan-Based Mucoadhesive Vaginal Tablets for Controlled Release of the Anti-HIV Drug Tenofovir.Pharmaceutics · 2019Article
- In situ fabrication of radiopaque microcapsules for oral delivery and real-time gastrointestinal tracking ofInternational journal of nanomedicine · 2018Article
- Chitosan-Based Nanomedicine to Fight Genital Candida Infections: Chitosomes.Marine drugs · 2017Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mucoadhesive drug therapy destined for localized drug treatment is gaining increasing importance in today's drug development. Chitosan, due to its known biodegradability, bioadhesiveness and excellent safety profile offers means to improve mucosal drug therapy. We have used chitosan as mucoadhesive polymer to develop liposomes able to ensure prolonged residence time at vaginal site. Two types of mucoadhesive liposomes, namely the chitosan-coated liposomes and chitosan-containing liposomes, where chitosan is both embedded and surface-available, were made of soy phosphatidylcholine with entrapped fluorescence markers of two molecular weights, FITC-dextran 4000 and 20,000, respectively. Both liposomal types were characterized for their size distribution, zeta potential, entrapment efficiency and the in vitro release profile, and compared to plain liposomes. The proof of chitosan being both surface-available as well as embedded into the liposomes in the chitosan-containing liposomes was found. The capability of the surface-available chitosan to interact with the model porcine mucin was confirmed for both chitosan-containing and chitosan-coated liposomes implying potential mucoadhesive behavior. Chitosan-containing liposomes were shown to be superior in respect to the simplicity of preparation, FITC-dextran load, mucoadhesiveness and in vitro release and are expected to ensure prolonged residence time on the vaginal mucosa providing localized sustained release of entrapped model substances.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.