ArticleJournal of cancer prevention2014
Anti-inflammatory Effects of Schisandra chinensis (Turcz.) Baill Fruit Through the Inactivation of Nuclear Factor-κB and Mitogen-activated Protein Kinases Signaling Pathways in Lipopolysaccharide-stimulated Murine Macrophages.
Article in Journal of cancer prevention, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 38 citations in OpenAlex.
- The Anti-Inflammatory and Skin Barrier Function Recovery Effects ofMedicina (Kaunas, Lithuania) · 2023Article
- Network Pharmacological Analysis on the Herbal Combinations for Mitigating Inflammation in Respiratory Tracts and Experimental Evaluation.Healthcare (Basel, Switzerland) · 2023Article
- Anti-arthritic effects of Schisandra chinensis extract in monosodium iodoacetate-induced osteoarthritis rats.Inflammopharmacology · 2022Article
- Anti-Inflammatory and Analgesic Effects ofNutrients · 2022Article
- Ameliorative effects of Schisandrin B on Schistosoma mansoni-induced hepatic fibrosis in vivo.PLoS neglected tropical diseases · 2021Article
- Antibacterial Effects of Schisandra chinensis Extract on Escherichia coli and its Applications in Cosmetic.Current microbiology · 2020Article
- The Effect of Schisandra chinensis Baillon on Cross-Talk between Oxidative Stress, Endoplasmic Reticulum Stress, and Mitochondrial Signaling Pathway in Testes of Varicocele-Induced SD Rat.International journal of molecular sciences · 2019Article
- Extract of Fructus Schisandrae chinensis Inhibits Neuroinflammation Mediator Production from Microglia via NF-κ B and MAPK Pathways.Chinese journal of integrative medicine · 2019Article
- Nutritional Interventions for Treating Cancer-Related Fatigue: A Qualitative Review.Nutrition and cancer · 2019Review
- Anti-Aging Effects ofEvidence-based complementary and alternative medicine : eCAM · 2019Article
- Inhibition of RANKL-stimulated osteoclast differentiation by Schisandra chinensis through down-regulation of NFATc1 and c-fos expression.BMC complementary and alternative medicine · 2018Article
- Schisandrol B and schisandrin B inhibit TGFβ1-mediated NF-κB activation via a Smad-independent mechanism.Oncotarget · 2018Article
- Schisandrae Fructus ethanol extract ameliorates inflammatory responses and articular cartilage damage in monosodium iodoacetate-induced osteoarthritis in rats.EXCLI journal · 2017Article
- Article
- The effect of clove-based herbal mouthwash on radiation-induced oral mucositis in patients with head and neck cancer: a single-blind randomized preliminary study.OncoTargets and therapy · 2016Article
- A comparative study between Wuweizi seed and its post-ethanol extraction residue in normal and hypercholesterolemic mice.Lipids in health and disease · 2015Article
- Pharmacokinetic and bioavailability study of angeloylgomisin H in rat plasma by UPLC-MS/MS.International journal of clinical and experimental medicine · 2015Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSchisandrae Fructus, the dried fruit of Schisandra chinensis (Turcz.) Baill. (Magnoliaceae), is widely used in traditional medicine for the treatment of a number of chronic inflammatory diseases. This study examined the anti-inflammatory effects of Schisandrae Fructus ethanol extract (SF) on the production of pro-inflammatory substances in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages.
methodsTo measure the effects of SF on pro-inflammatory mediator and inflammatory cytokine's expression and production in RAW 264.7 cells, we used the following methods: cell viability assay, Griess reagent assay, enzyme-linked immunosorbent assay, reverse transcriptase-polymerase chain reaction, Western blotting analysis and immunofluorescence staining.
resultsStimulation of the RAW 264.7 cells with LPS caused an elevated production of nitric oxide (NO), tumor necrosis factor α (TNF-α) and interleukin (IL)-1β, which was markedly inhibited by the pretreatment with SF without causing any cytotoxic effects. SF also inhibited the expression of inducible NO synthase, TNF-α, and IL-1β protein and their mRNAs in LPS-stimulated RAW 264.7 cells. Furthermore, SF attenuated LPS-induced nuclear translocation of nuclear factor-κB (NF-κB) by reducing inhibitory-κB degradation, and reduced the phosphorylation of mitogen-activated protein kinases (MAPKs), implying that SF regulated LPS-induced NF-κB-dependent inflammatory pathways through suppression of MAPKs activation.
conclusionsSF may be useful for the treatment of various inflammatory diseases.
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