Evidence map›Paper›PMID 25574446›Full record

ArticleBiomedical optics express2014

Ultrahigh speed endoscopic optical coherence tomography for gastroenterology.

Tsung-Han Tsai, Hsiang-Chieh Lee, Osman O Ahsen, Kaicheng Liang, Michael G Giacomelli, Benjamin M Potsaid, Yuankai K Tao, Vijaysekhar Jayaraman, Marisa Figueiredo, Qin Huang and 3 more

Open access · goldAbstract read
In one paragraph

Article in Biomedical optics express, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 41 citations in OpenAlex.

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  8. Real-timeBiomedical optics express · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 1 country.

Tsung-Han TsaiDepartment of Electrical Engineering & Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, 50 Vassar Street, Cambridge, MA 02139, USA.
Hsiang-Chieh LeeDepartment of Electrical Engineering & Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, 50 Vassar Street, Cambridge, MA 02139, USA.
Osman O AhsenDepartment of Electrical Engineering & Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, 50 Vassar Street, Cambridge, MA 02139, USA.
Kaicheng LiangDepartment of Electrical Engineering & Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, 50 Vassar Street, Cambridge, MA 02139, USA.
Michael G GiacomelliDepartment of Electrical Engineering & Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, 50 Vassar Street, Cambridge, MA 02139, USA.
Benjamin M PotsaidDepartment of Electrical Engineering & Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, 50 Vassar Street, Cambridge, MA 02139, USA ; Advanced Imaging Group, Thorlabs, Inc., 56 Sparta Avenue, Newton, NJ 07860, USA.
Yuankai K TaoDepartment of Electrical Engineering & Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, 50 Vassar Street, Cambridge, MA 02139, USA.
Vijaysekhar JayaramanPraevium Research, Inc., 5385 Hollister Avenue, Santa Barbara, CA 93111, USA.
Marisa FigueiredoVeteran Affairs Boston Healthcare System and Harvard Medical School, 25 Shattuck St, Boston, MA 02115, USA.
Qin HuangVeteran Affairs Boston Healthcare System and Harvard Medical School, 25 Shattuck St, Boston, MA 02115, USA.
Alex E CableAdvanced Imaging Group, Thorlabs, Inc., 56 Sparta Avenue, Newton, NJ 07860, USA.
James FujimotoDepartment of Electrical Engineering & Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, 50 Vassar Street, Cambridge, MA 02139, USA ; jgfuji@mit.edu.
Hiroshi MashimoVeteran Affairs Boston Healthcare System and Harvard Medical School, 25 Shattuck St, Boston, MA 02115, USA.
Massachusetts Institute of Technology · USVA Boston Healthcare System · USVassar College · USHarvard University · USPraevium Research (United States) · USThorlabs (United States) · US

Funding

Novel Optical Diagnostics with Optical Coherence TomographyR01EY011289 · NEI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI JAMES G FUJIMOTO · 1995 to 2026
$9.5M
OPTICAL BIOPSY USING OPTICAL COHERENCE TOMOGRAPHYR01CA075289 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI FUJIMOTO, JAMES G, MASHIMO, HIROSHI · 1997 to 2018
$4.8M
Ultrahigh speed and resolution OCT/OCM using broadband swept VCSEL technologyR44CA101067 · NCI · PRAEVIUM RESEARCH, INC. · PI JAYARAMAN, VIJAYSEKHAR · 2003 to 2012
$2.9M
Intraoperative real time breast cancer margin assessment with nonlinear microscopR01CA178636 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI CONNOLLY, JAMES, FUJIMOTO, JAMES G · 2013 to 2018
$1.7M
VCSEL technology for ultrahigh speed OCT retinal and anterior eye imagingR44EY022864 · NEI · PRAEVIUM RESEARCH, INC. · PI JAYARAMAN, VIJAYSEKHAR · 2012 to 2014
$1.1M
NCI NIH HHS R01 CA075289NCI NIH HHS R01 CA178636NCI NIH HHS R44 CA101067NEI NIH HHS R01 EY011289NEI NIH HHS R44 EY022864
6 · The paper itself

Abstract

We describe an ultrahigh speed endoscopic swept source optical coherence tomography (OCT) system for clinical gastroenterology using a vertical-cavity surface-emitting laser (VCSEL) and micromotor imaging catheter. The system had a 600 kHz axial scan rate and 8 µm axial resolution in tissue. Imaging was performed with a 3.2 mm diameter imaging catheter at 400 frames per second with a 12 µm spot size. Three-dimensional OCT (3D-OCT) imaging was performed in patients with a cross section of pathologies undergoing upper and lower endoscopy. The use of distally actuated imaging catheters enabled OCT imaging with more flexibility, such as volumetric imaging in the small intestine and the assessment of hiatal hernia using retroflex imaging. The high rotational scanning stability of the micromotor enabled 3D volumetric imaging with micron scale volumetric accuracy for both en face OCT and cross-sectional imaging, as well as OCT angiography (OCTA) for 3D visualization of subsurface microvasculature. The ability to perform both structural and functional 3D OCT imaging in the GI tract with microscopic accuracy should enable a wide range of studies and enhance the sensitivity and specificity of OCT for detecting pathology.

Indexed as

(110.2350) Fiber optics imaging(110.6880) Three-dimensional image acquisition(120.3890) Medical optics instrumentation(120.5800) Scanners(140.7260) Vertical cavity surface emitting lasers(170.2150) Endoscopic imaging(170.2680) Gastrointestinal(170.3880) Medical and biological imaging(170.4500) Optical coherence tomography

Identifiers

PMID25574446
PMCPMC4285613
OpenAlexW2109970462

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.