ArticleBiomaterials science2015
In Vitro Study of Directly Bioprinted Perfusable Vasculature Conduits.
Article in Biomaterials science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
70 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Engineering Functional Cardiac Tissues for Regenerative Medicine Applications.Current cardiology reports · 2019Pooled it
- Emerging Polysaccharide-Based Biomaterials in 3D Bioprinting: Materials, Biomedical Applications, and Future Perspectives.ACS omega · 2026Review
- Coconut Oil as Lipid-Based 3D-Printable Sacrificial Material for the Facile Biofabrication of Precise Perfusable Microchannels and Freeform Hydrogel Structures.Small science · 2026Article
- 3D bioprinting for cancer modeling and drug screening.Biomarker research · 2026Review
- Shaping soft hydrogels into 3D, multiscale, perfusable models using multimodal printing.Biofabrication · 2026Article
- Engineering in vitro vascular microsystems.Microsystems & nanoengineering · 2025Review
- Hydrogel-Based Bioinks for Coaxial and Triaxial Bioprinting: A Review of Material Properties, Printing Techniques, and Applications.Polymers · 2025Review
- Applications of 3D Bioprinting in Oral and Maxillofacial Surgery: An Insight.Journal of maxillofacial and oral surgery · 2024Review
- Harnessing the power of bioprinting for the development of next-generation models of thrombosis.Bioactive materials · 2024Review
- Effects of Coaxial Nozzle's Inner Nozzle Diameter on Filament Strength and Gelation in Extrusion-Based 3D Printing with In Situ Ionic Crosslinking.Biomimetics (Basel, Switzerland) · 2024Article
- Nozzle Innovations That Improve Capacity and Capabilities of Multimaterial Additive Manufacturing.ACS engineering Au · 2024Review
- A novel semi-flexible coaxial nozzle based on fluid dynamics effects and its self-centering performance study.Scientific reports · 2024Article
- Review
- Formation of Stable Vascular Networks by 3D Coaxial Printing and Schiff-Based Reaction.Gels (Basel, Switzerland) · 2024Article
- Droplet bioprinting of acellular and cell-laden structures at high-resolutions.Biofabrication · 2024Article
- Advancing cardiac regeneration through 3D bioprinting: methods, applications, and future directions.Heart failure reviews · 2024Review
- 3D bioprinting of microorganisms: principles and applications.Bioprocess and biosystems engineering · 2024Review
- Rising role of 3D-printing in delivery of therapeutics for infectious disease.Journal of controlled release : official journal of the Controlled Release Society · 2024Review
- Three Dimensional Bioprinting for Hepatic Tissue Engineering: From In Vitro Models to Clinical Applications.Tissue engineering and regenerative medicine · 2024Review
- Synergistic coupling between 3D bioprinting and vascularization strategies.Biofabrication · 2023Review
10 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
The ability to create three dimensional (3D) thick tissues is still a major tissue engineering challenge. It requires the development of a suitable vascular supply for an efficient media exchange. An integrated vasculature network is particularly needed when building thick functional tissues and/or organs with high metabolic activities, such as the heart, liver and pancreas. In this work, human umbilical vein smooth muscle cells (HUVSMCs) were encapsulated in sodium alginate and printed in the form of vasculature conduits using a coaxial deposition system. Detailed investigations were performed to understand the dehydration, swelling and degradation characteristics of printed conduits. In addition, because perfusional, permeable and mechanical properties are unique characteristics of natural blood vessels, for printed conduits these properties were also explored in this work. The results show that cells encapsulated in conduits had good proliferation activities and that their viability increased during prolonged in vitro culture. Deposition of smooth muscle matrix and collagen was observed around the peripheral and luminal surface in long-term cultured cellular vascular conduit through histology studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.