ArticleMediterranean journal of hematology and infectious diseases2015
Prevalence of alpha thalassemia in microcytic anemia: a tertiary care experience from north India.
Article in Mediterranean journal of hematology and infectious diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 10 citations in OpenAlex.
- A machine-learning capillary electrophoresis-based pattern to identify suspected sickle cell trait and α-thalassemia co-inheritance.Advances in laboratory medicine · 2026Article
- Prevalence of 3.7 and 4.2 deletions in Sudanese patients with red cells hypochromia and microcytosis.BMC research notes · 2020Article
- Deletional Alpha-Thalassemia Alleles in Amazon Blood Donors.Advances in hematology · 2020Article
- Inherited haemochromatosis with C282Y mutation in a patient with alpha-thalassaemia: a treatment dilemma.BMJ case reports · 2018Article
- Iron deficiency anemia interfering the diagnosis of compound heterozygosity for Hb constant spring and Hb Paksé: The first case report.Journal of clinical laboratory analysis · 2018Article
- Knowledge, Attitude and Practice of Carrier Thalassemia Marriage Volunteer in Prevention of Major Thalassemia.Global journal of health science · 2015Article
- Undiagnosed Hemoglobinopathies: A potential threat to the premarital screening program.Pakistan journal of medical sciencesArticle
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionCases with microcytosis not responding adequately to iron supplementation are diagnostic dilemma and have been reported to harbor alpha (α) thalassemia mutations. The aim of this study was to determine the common α globin gene deletions in cases with microcytic anemia.
methodsFifty four patients selected (22 females and 32 males) had microcytic anemia (MCV < 80 fl, Hb <12gm/dl) with raised TRBC (> 5M/mm3) but normal Hb HPLC. They had either low or normal Transferrin Saturation (TS). Gap-PCR for four common α-gene deletions (-α(3.7), -α(4.2), - -α(SA) and --α(SEA)) was done.
resultsOut of the total fifty-four cases nineteen (35.2%) cases were found to have α gene mutations; Three homozygous and sixteen heterozygous cases including -α(3.7) deletions and a single case of -- α (SA) ; but no -α(4.2) and -(SEA) mutations were found.
conclusionα gene mutations can confound iron deficiency anemia, but no RBC indices, or a discriminant function can identify it is presence Molecular studies have to be resorted to. Gap PCR for common α thalassemia mutation including -α (SA) should be done even in the face of low iron stores in subjects who respond incompletely to iron supplementation.
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