Evidence map›Paper›PMID 25574094›Full record

ArticleWorld journal of gastroenterology2015

Reactivity against microsatellite instability-induced frameshift mutations in patients with inflammatory bowel disease.

Florian Kuehn, Ernst Klar, Anja Bliemeister, Michael Linnebacher

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of gastroenterology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 95% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Florian KuehnFlorian Kuehn, Ernst Klar, Anja Bliemeister, Michael Linnebacher, Department of General, Thoracic, Vascular and Transplantation Surgery, Molecular Oncology and Immunotherapy, University of Rostock, 18057 Rostock, Germany.
Ernst KlarFlorian Kuehn, Ernst Klar, Anja Bliemeister, Michael Linnebacher, Department of General, Thoracic, Vascular and Transplantation Surgery, Molecular Oncology and Immunotherapy, University of Rostock, 18057 Rostock, Germany.
Anja BliemeisterFlorian Kuehn, Ernst Klar, Anja Bliemeister, Michael Linnebacher, Department of General, Thoracic, Vascular and Transplantation Surgery, Molecular Oncology and Immunotherapy, University of Rostock, 18057 Rostock, Germany.
Michael LinnebacherFlorian Kuehn, Ernst Klar, Anja Bliemeister, Michael Linnebacher, Department of General, Thoracic, Vascular and Transplantation Surgery, Molecular Oncology and Immunotherapy, University of Rostock, 18057 Rostock, Germany.
University of Rostock · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo analyze the cellular immune response towards microsatellite-instability (MSI)-induced frameshift-peptides (FSPs) in patients suffering from inflammatory bowel disease (IBD) with and without thiopurine-based immunosuppressive treatment.

methodsFrequencies of peripheral blood T cell responses of IBD patients (n = 75) against FSPs derived from 14 microsatellite-containing candidate genes were quantified by interferon-γ enzyme-linked immunospot. T cells derived from 20 healthy individuals served as controls.

resultsSignificant T cell reactivities against MSI-induced FSPs were observed in 59 of 75 IBD patients (78.7%). This was significantly more as we could observe in 20 healthy controls (P = 0.001). Overall, the reactivity was significantly influenced by thiopurine treatment (P = 0.032) and duration of disease (P = 0.002) but not by duration or cumulative amount of thiopurine therapy (P = 0.476). Unexpected, 15 of 24 (62.5%) IBD patients without prior thiopurine treatment also showed increased FSP-specific immune responses (P = 0.001).

conclusionThese findings propose FSPs as potential novel class of inflammation-associated antigens and this in turn may have implications for screening, diagnosis as well as clinical management of patients suffering from IBD and other inflammatory conditions.

Indexed as

Frameshift MutationMicrosatellite InstabilityAdultAgedAged, 80 and overAutoantigensCase-Control StudiesFemaleGenetic MarkersGenetic Predisposition to DiseaseHumansImmunosuppressive AgentsInflammatory Bowel DiseasesMaleMercaptopurineMiddle AgedAutoantigensazathiopurineGenetic MarkersImmunosuppressive AgentsMercaptopurineFrameshift peptidesImmune responseInflammatory bowel diseasMicrosatellite-instabilityThiopurine

Identifiers

PMID25574094
PMCPMC4284338
OpenAlexW2033783652

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.