ArticleThe Journal of cell biology1989
Translational diffusion of class II major histocompatibility complex molecules is constrained by their cytoplasmic domains.
Article in The Journal of cell biology, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 55 citations in OpenAlex.
- Single-Particle Tracking Reveals Anti-Persistent Subdiffusion in Cell Extracts.Entropy (Basel, Switzerland) · 2021Article
- Spatial EGFR Dynamics and Metastatic Phenotypes Modulated by Upregulated EphB2 and Src Pathways in Advanced Prostate Cancer.Cancers · 2019Article
- Assessing metastatic potential of breast cancer cells based on EGFR dynamics.Scientific reports · 2019Article
- The actin cytoskeleton modulates the activation of iNKT cells by segregating CD1d nanoclusters on antigen-presenting cells.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Nanoscale organization and dynamics of the siglec CD22 cooperate with the cytoskeleton in restraining BCR signalling.The EMBO journal · 2016Article
- Article
- Immunological Functions of the Membrane Proximal Region of MHC Class II Molecules.F1000Research · 2016Review
- Motor and tail homology 1 (Th1) domains antagonistically control myosin-1 dynamics.Biophysical journal · 2014Article
- Improved analysis for determining diffusion coefficients from short, single-molecule trajectories with photoblinking.Langmuir : the ACS journal of surfaces and colloids · 2013Article
- Antigen-specific blocking of CD4-specific immunological synapse formation using BPI and current therapies for autoimmune diseases.Medicinal research reviews · 2012Review
- Single-particle tracking of immunoglobulin E receptors (FcεRI) in micron-sized clusters and receptor patches.FEBS letters · 2012Article
- The membrane skeleton controls diffusion dynamics and signaling through the B cell receptor.Immunity · 2010Article
- Translational diffusion of individual class II MHC membrane proteins in cells.Biophysical journal · 2002Article
- Calculations show substantial serial engagement of T cell receptors.Biophysical journal · 2001Article
- Anomalous diffusion of major histocompatibility complex class I molecules on HeLa cells determined by single particle tracking.Biophysical journal · 1999Article
- Interferometric fringe fluorescence photobleaching recovery interrogates entire cell surfaces.Biophysical journal · 1998Article
- Single-particle tracking: the distribution of diffusion coefficients.Biophysical journal · 1997Article
- Article
- Effect of hydrodynamic interactions on the diffusion of integral membrane proteins: diffusion in plasma membranes.Biophysical journal · 1995Article
- Distinct structural compartmentalization of the signal transducing functions of major histocompatibility complex class II (Ia) molecules.The Journal of experimental medicine · 1994Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Site-directed mutagenesis in vitro was used to introduce stop codons in the genomic DNA of the alpha and beta chains of the murine class II major histocompatibility complex antigen, I-Ak. Mutated DNA was transfected into B lymphoma cells that were then selected by neomycin resistance and for their ability to express I-Ak molecules on their plasma membrane. The translational diffusion coefficient (Dlat) of I-Ak molecules composed of a wild-type beta chain paired with an alpha chain missing either 6 or 12 amino acids from the cytoplasmic domain is on the average threefold higher than the Dlat of wild-type I-Ak molecules as measured by fluorescence photobleaching and recovery. The removal of 12 amino acids from the cytoplasmic domain of the beta chain did not change the Dlat value from that of wild-type I-Ak if the truncated beta chain was paired with a wild-type alpha chain. Removing all amino acids of the cytoplasmic domains of both the alpha and beta chains resulted in a 10-fold increase in the Dlat, the highest value for any of the truncated I-Ak molecules tested. These data indicate that the carboxy-terminal six amino acids of the cytoplasmic domain of the alpha chain and the six plasma membrane-proximal amino acids of the beta chain are important in constraining the translational diffusion of I-Ak molecules in the plasma membrane.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.