Evidence map›Paper›PMID 25573422›Full record

ArticleScientific reports2015

Decreased deformability of lymphocytes in chronic lymphocytic leukemia.

Yi Zheng, Jun Wen, John Nguyen, Mark A Cachia, Chen Wang, Yu Sun

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Manipulation and Mechanical Deformation of Leukemia Cells by High-Frequency Ultrasound Single Beam.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2022
    Article
  10. Cancer cell mechanobiology: a new frontier for cancer research.Journal of the National Cancer Center · 2022
    Review
  11. Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yi Zheng1] Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, ON, Canada [2] Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON, Canada.
Jun WenDepartment of Mechanical and Industrial Engineering, University of Toronto, Toronto, ON, Canada.
John NguyenDepartment of Mechanical and Industrial Engineering, University of Toronto, Toronto, ON, Canada.
Mark A CachiaDepartment of Mechanical and Industrial Engineering, University of Toronto, Toronto, ON, Canada.
Chen Wang1] Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, ON, Canada [2] Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.
Yu Sun1] Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, ON, Canada [2] Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON, Canada [3] Department of Electrical and Computer Engineering, University of Toronto, Toronto, ON, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This paper reports the first study of stiffness/deformability changes of lymphocytes in chronic lymphocytic leukemia (CLL) patients, demonstrating that at the single cell level, leukemic metastasis progresses are accompanied by biophysical property alterations. A microfluidic device was utilized to electrically measure cell volume and transit time of single lymphocytes from healthy and CLL patients. The results from testing thousands of cells reveal that lymphocytes from CLL patients have higher stiffness (i.e., lower deformability), as compared to lymphocytes in healthy samples, which was also confirmed by AFM indentation tests. This observation is in sharp contrast to the known knowledge on other types of metastatic cells (e.g., breast and lung cancer cells) whose stiffness becomes lower as metastasis progresses.

Indexed as

Blood DonorsCell SizeHemorheologyHumansLeukemia, Lymphocytic, Chronic, B-CellLymphocytesMicrofluidic Analytical TechniquesMicroscopy, Atomic Force

Identifiers

PMID25573422
PMCPMC4287721

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.