Evidence map›Paper›PMID 25573070›Full record

Trial reportBrain stimulation

Effects of Stochastic Vestibular Galvanic Stimulation and LDOPA on Balance and Motor Symptoms in Patients With Parkinson's Disease.

Ghazaleh Samoudi, Maria Jivegård, Ajitkumar P Mulavara, Filip Bergquist

Open access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Brain stimulation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 2 pooled it
3.6field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 2 syntheses or guidelines pooled it, 96 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Ghazaleh SamoudiDepartment of Pharmacology, Inst of Neuroscience and Physiology, University of Gothenburg, Box 431, 405 30 Göteborg, Sweden.
Maria JivegårdDepartment of Pharmacology, Inst of Neuroscience and Physiology, University of Gothenburg, Box 431, 405 30 Göteborg, Sweden.
Ajitkumar P MulavaraUniversities Space Research Association, Houston, TX, USA.
Filip BergquistDepartment of Pharmacology, Inst of Neuroscience and Physiology, University of Gothenburg, Box 431, 405 30 Göteborg, Sweden. Electronic address: filip.bergquist@gu.se.
University of Gothenburg · SEUniversities Space Research Association · US

Funding

Epidemiologic research on screening for vestibular and balance disorders: supplement for people with Alzheimer's diseaseR01DC009031 · NIDCD · BAYLOR COLLEGE OF MEDICINE · PI COHEN, HELEN S · 2008 to 2019
$5.0M
NIDCD NIH HHS R01 DC009031NIDCD NIH HHS R01-DC009031
6 · The paper itself

Abstract

backgroundBalance problems contribute to reduced quality of life in Parkinson's disease (PD) and available treatments are often insufficient for treating axial and postural motor symptoms.

objectiveTo investigate the safety of use and possible effects of stochastic vestibular stimulation (SVS) alone and combined with LDOPA in patients with PD.

methodsSVS or sham stimulation was administered to 10 PD patients in a double-blind placebo controlled cross-over pilot study. Motor symptoms and balance were evaluated in a defined off-medication state and after a 200 mg test dose of LDOPA, using UPDRS-III, Posturo-Locomotor-Manual (PLM) movement times (MT), static posturography and force plate measurements of the correcting response to a balance perturbation.

resultsPatients did not detect when SVS was active, but SVS increased nausea after LDOPA in two patients. Mixed model analysis demonstrated that SVS improved balance corrections after a backward perturbation and shortened the postural response time. In static posturography there was significant interaction between effects of SVS, medication and proprioceptive input (standing on foam vs. on hard support) and SVS decreased the total sway-path with eyes closed and off medication. As expected, LDOPA improved the UPDRS-III scores and MT. There was an interaction between the effect of SVS and LDOPA on UPDRS-III partly because of reduced UPDRS-III scores with SVS in the off-medication state.

conclusionsShort term use of SVS is safe, improves corrective postural responses and may have a small positive effect on motor symptoms in PD patients off treatment.

Indexed as

Postural BalanceAdultAgedAntiparkinson AgentsCombined Modality TherapyCross-Over StudiesDouble-Blind MethodElectric Stimulation TherapyFemaleHumansLevodopaMaleMiddle AgedMovement DisordersParkinson DiseasePilot ProjectsAntiparkinson AgentsLevodopaLevodopaParkinson's diseasePostureVestibular stimulation

Identifiers

PMID25573070
PMCPMC5386963
OpenAlexW1998085788

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.