ArticleScientific reports2015
Plasma-activated medium suppresses choroidal neovascularization in mice: a new therapeutic concept for age-related macular degeneration.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 54 citations in OpenAlex.
- Plasma-Activated Medium Suppresses Lung Cancer H1299 Cell Migration through the MAPK Pathway.Cell biochemistry and biophysics · 2026Article
- Treatment and Cleaning of Contact Lenses with Plasma-Activated Solutions.Pathogens (Basel, Switzerland) · 2026Article
- Evaluation of Anti-VEGFR2 Specific Photoimmunotherapy for Targeted Regression of Neovascularization in an AMD Model.Investigative ophthalmology & visual science · 2025Article
- METTL3-mediated m6A modification of HMGA2 mRNA promotes subretinal fibrosis and epithelial-mesenchymal transition.Journal of molecular cell biology · 2023Article
- Dimethyl Fumarate Protects Retinal Pigment Epithelium from Blue Light-Induced Oxidative Damage via the Nrf2 Pathway.Antioxidants (Basel, Switzerland) · 2022Article
- Inherited Retinal Dystrophies: Role of Oxidative Stress and Inflammation in Their Physiopathology and Therapeutic Implications.Antioxidants (Basel, Switzerland) · 2022Review
- Malondialdehyde-Modified Photoreceptor Outer Segments Promote Choroidal Neovascularization in Mice.Translational vision science & technology · 2022Article
- Applications of Plasma-Activated Liquid in the Medical Field.Biomedicines · 2021Review
- Toxicity Assessment of Long-Term Exposure to Non-Thermal Plasma Activated Water in Mice.International journal of molecular sciences · 2021Article
- Evaluating the effect of cold plasma on the healing of gingival wound.Journal of diabetes and metabolic disorders · 2021Article
- Tendon repair by plasma jet treatment.Journal of diabetes and metabolic disorders · 2021Article
- Selective Anti-Cancer Effects of Plasma-Activated Medium and Its High Efficacy with Cisplatin on Hepatocellular Carcinoma with Cancer Stem Cell Characteristics.International journal of molecular sciences · 2021Article
- Argon Atmospheric Plasma Treatment Promotes Burn Healing by Stimulating Inflammation and Controlling the Redox State.Inflammation · 2020Article
- The efficacy and safety of cold atmospheric plasma as a novel therapy for diabetic wound in vitro and in vivo.International wound journal · 2020Article
- Cold-Atmospheric Plasma Induces Tumor Cell Death in Preclinical In Vivo and In Vitro Models of Human Cholangiocarcinoma.Cancers · 2020Article
- Autophagy promotes MSC-mediated vascularization in cutaneous wound healing via regulation of VEGF secretion.Cell death & disease · 2018Article
- Nutritional Supplementation Inhibits the Increase in Serum Malondialdehyde in Patients with Wet Age-Related Macular Degeneration.Oxidative medicine and cellular longevity · 2017Article
- Salvianolic Acid A Inhibits OX-LDL Effects on Exacerbating Choroidal Neovascularization via Downregulating CYLD.Oxidative medicine and cellular longevity · 2017Article
- Plasma-activated medium selectively eliminates undifferentiated human induced pluripotent stem cells.Regenerative therapy · 2016Article
- Investigation on the effects of the atmospheric pressure plasma on wound healing in diabetic rats.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
14 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Choroidal neovascularization (CNV) is the main pathogenesis of age-related macular degeneration (AMD), which leads to severe vision loss in many aged patients in most advanced country. CNV compromises vision via hemorrhage and retinal detachment on account of pathological neovascularization penetrating the retina. Plasma medicine represents the medical application of ionized gas "plasma" that is typically studied in the field of physical science. Here we examined the therapeutic ability of plasma-activated medium (PAM) to suppress CNV. The effect of PAM on vascularization was assessed on the basis of human retinal endothelial cell (HREC) tube formation. In mice, laser photocoagulation was performed to induce CNV (laser-CNV), followed by intravitreal injection of PAM. N-Acetylcysteine was used to examine the role of reactive oxygen species in PAM-induced CNV suppression. Fundus imaging, retinal histology examination, and electroretinography (ERG) were also performed to evaluate PAM-induced retinal toxicity. Interestingly, HREC tube formation and laser-CNV were both reduced by treatment with PAM. N-acetylcysteine only partly neutralized the PAM-induced reduction in laser-CNV. In addition, PAM injection had no effect on regular retinal vessels, nor did it show retinal toxicity in vivo. Our findings indicate the potential of PAM as a novel therapeutic agent for suppressing CNV.
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