Evidence map›Paper›PMID 25573051›Full record

ArticleNanoscale2015

Optical and photoacoustic dual-modality imaging guided synergistic photodynamic/photothermal therapies.

Xuefeng Yan, Hao Hu, Jing Lin, Albert J Jin, Gang Niu, Shaoliang Zhang, Peng Huang, Baozhong Shen, Xiaoyuan Chen

Open access · greenAbstract read
In one paragraph

Article in Nanoscale, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
6.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 97 citations in OpenAlex.

  1. Review
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  17. Photodynamic Therapy Based on Graphene and MXene in Cancer Theranostics.Frontiers in bioengineering and biotechnology · 2019
    Review
  18. Review
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Xuefeng YanDepartment of Radiology, the Fourth Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Hao Hu
Jing Lin
Albert J Jin
Gang Niu
Shaoliang Zhang
Peng Huang
Baozhong Shen
Xiaoyuan Chen
National Institute of Biomedical Imaging and Bioengineering · USNational Institutes of Health · USBethesda University · USFourth Affiliated Hospital of Harbin Medical University · CN

Funding

Laboratory of Molecular Imaging and NanomedicineZIAEB000073 · NIBIB · NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING · PI CHEN, XIAOYUAN · 2010 to 2020
$32.8M
Biomedical Studies and Cellular Imaging via Atomic Force MicroscopyZIAEB000015 · NIBIB · NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING · PI JIN, ALBERT J · 2009 to 2025
$5.8M
Intramural NIH HHS Z99 EB999999Intramural NIH HHS ZIA EB000073
6 · The paper itself

Abstract

Phototherapies such as photodynamic therapy (PDT) and photothermal therapy (PTT), due to their specific spatiotemporal selectivity and minimal invasiveness, have been widely investigated as alternative treatments of malignant diseases. Graphene and its derivatives not only have been used as carriers to deliver photosensitizers for PDT, but also as photothermal conversion agents (PTCAs) for PTT. Herein, we strategically designed and produced a novel photo-theranostic platform based on sinoporphyrin sodium (DVDMS) photosensitizer-loaded PEGylated graphene oxide (GO-PEG-DVDMS) for enhanced fluorescence/photoacoustic (PA) dual-modal imaging and combined PDT and PTT. The GO-PEG carrier drastically improves the fluorescence of loaded DVDMS via intramolecular charge transfer. Concurrently, DVDMS significantly enhances the near-infrared (NIR) absorption of GO for improved PA imaging and PTT. The cancer theranostic capability of the as-prepared GO-PEG-DVDMS was carefully investigated both in vitro and in vivo. This novel theranostics is well suited for fluorescence/PA dual-modal imaging and synergistic PDT/PTT.

Indexed as

PhotochemotherapyAcousticsAnimalsBody WeightGraphiteLightMiceMice, NudeMicroscopy, Atomic ForceMicroscopy, FluorescenceNanotechnologyNeoplasm TransplantationOptics and PhotonicsPermeabilityPhotochemistryPhotosensitizing AgentsGraphitePhotosensitizing AgentsPolyethylene GlycolsPorphyrinsReactive Oxygen SpeciesSinglet Oxygensinoporphyrin sodium

Identifiers

PMID25573051
PMCPMC5257288
OpenAlexW2158956991

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.