Evidence map›Paper›PMID 25572998›Full record

ArticleBiostatistics (Oxford, England)2015

Assessment of critical exposure and outcome windows in time-to-event analysis with application to air pollution and preterm birth study.

Howard H Chang, Joshua L Warren, Lnydsey A Darrow, Brian J Reich, Lance A Waller

Open access · bronzeAbstract read
In one paragraph

Article in Biostatistics (Oxford, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 2 pooled it
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 2 syntheses or guidelines pooled it, 79 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  5. Review
  6. Article
  7. Article
  8. Distributed lag interaction model with index modification.Biostatistics (Oxford, England) · 2025
    Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Pregnancy exposure to PMEnvironment international · 2024
    Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Howard H ChangDepartment of Biostatistics and Bioinformatics, Emory University, Atlanta, GA 30322, USA howard.chang@emory.edu.
Joshua L WarrenDepartment of Biostatistics, Yale University, New Haven, CT 06510, USA.
Lnydsey A DarrowDepartment of Epidemiology, Emory University, Atlanta, GA 30322, USA.
Brian J ReichDepartment of Statistics, North Carolina State University, Raleigh, NC 27695, USA.
Lance A WallerDepartment of Biostatistics and Bioinformatics, Emory University, Atlanta, GA 30322, USA.
Emory University · USNorth Carolina State University · USYale University · US

Funding

Space-time Modeling for Linking Climate Change,Pollutant Exposure, Built EnvironmR01ES014843 · NIEHS · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI REICH, BRIAN J. · 2008 to 2013
$2.0M
Statistical Methods for Exposure Uncertainty in Air Pollution and Health StudiesR21ES022795 · NIEHS · EMORY UNIVERSITY · PI CHANG, HOWARD H · 2014 to 2015
$442k
NIEHS NIH HHS R01 ES014843NIEHS NIH HHS R21 ES022795NIEHS NIH HHS R21ES022795-01A1
6 · The paper itself

Abstract

In reproductive epidemiology, there is a growing interest to examine associations between air pollution exposure during pregnancy and the risk of preterm birth (PTB). One important research objective is to identify critical periods of exposure and estimate the associated effects at different stages of pregnancy. However, population studies have reported inconsistent findings. This may be due to limitations from the standard analytic approach of treating PTB as a binary outcome without considering time-varying exposures together over the course of pregnancy. To address this research gap, we present a Bayesian hierarchical model for conducting a comprehensive examination of gestational air pollution exposure by estimating the joint effects of weekly exposures during different vulnerable periods. Our model also treats PTB as a time-to-event outcome to address the challenge of different exposure lengths among ongoing pregnancies. The proposed model is applied to a dataset of geocoded birth records in the Atlanta metropolitan area between 1999-2005 to examine the risk of PTB associated with gestational exposure to ambient fine particulate matter [Formula: see text]m in aerodynamic diameter (PM[Formula: see text]). We find positive associations between PM[Formula: see text] exposure during early and mid-pregnancy, and evidence that associations are stronger for PTBs occurring around week 30.

Indexed as

Air PollutionBayes TheoremBiostatisticsComputer SimulationFemaleGeorgiaHumansInfant, NewbornModels, StatisticalParticulate MatterPregnancyPremature BirthPrenatal Exposure Delayed EffectsRisk FactorsParticulate MatterAir pollutionFine particulate matterJoint effectsPreterm birthTime-dependent exposureTime-to-event modelTime-varying effect

Identifiers

PMID25572998
PMCPMC5963471
OpenAlexW2162547226

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.