Evidence map›Paper›PMID 25572843›Full record

ArticleEMBO reports2015

Positive feedback regulation of type I interferon by the interferon-stimulated gene STING.

Feng Ma, Bing Li, Yongxin Yu, Shankar S Iyer, Mingyu Sun, Genhong Cheng

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EMBO reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 95 papers.

0numbers the graph read from it
0cells of the map it votes in
95citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

95 citing papers in PubMed, 144 citations in OpenAlex.

  1. Trial
  2. Identification ofFrontiers in immunology · 2018
    Trial
  3. Gut microbes · 2026
    Article
  4. RNF213-dependent lytic destruction ofProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Autoinflammatory syndromes of STING and TREX1 dysfunction.The Journal of clinical investigation · 2026
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. When ISG15 is involved in inflammation.Frontiers in immunology · 2026
    Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Amyloid-beta glycation induces neuronal mitochondrial dysfunction and Alzheimer's pathogenesis via VDAC1-dependent mtDNA efflux.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  20. Review

35 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 2 countries.

Feng MaDepartment of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA, USA.
Bing LiDepartment of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA, USA.
Yongxin YuDivision of Oral Biology and Medicine, School of Dentistry and Broad Stem Cell Research Center, University of California, Los Angeles, CA, USA.
Shankar S IyerDepartment of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA, USA.
Mingyu SunDepartment of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA, USA Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Genhong ChengDepartment of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA, USA gcheng@mednet.ucla.edu.
University of California, Los Angeles · US

Funding

UCLA Tumor Immunology Training ProgramT32CA009120 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Steven M. Dubinett, MICHAEL A TEITELL · 1985 to 2026
$10.3M
Vitamin D Metabolism in LeprosyP50AR063020 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MODLIN, ROBERT L · 2012 to 2016
$7.8M
Viral Mediated Type I Interferon InductionR01AI069120 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHENG, GENHONG · 2006 to 2021
$6.0M
Role of IRF3 and RXRa Crosstalk in Host Response to Viral InfectionsR01AI078389 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHENG, GENHONG · 2009 to 2013
$1.8M
NCI NIH HHS T32 CA009120NIAID NIH HHS AI069120NIAID NIH HHS R01 AI069120NIAID NIH HHS R01 AI078389NIAID NIH HHS R01AI078389NIAMS NIH HHS P50 AR063020
6 · The paper itself

Abstract

Stimulator of interferon genes (STING) is an important regulator of the innate immune response to cytoplasmic DNA. However, regulation of STING itself is largely unknown. Here, we show that STING transcription is induced by innate immune activators, such as cyclic dinucleotides (CDNs), through an IFNAR1- and STAT1-dependent pathway. We also identify a STAT1 binding site in the STING promoter that contributes to the activation of STING transcription. Furthermore, we show that induction of STING mediates the positive feedback regulation of CDN-triggered IFN-I. Thus, our study demonstrates that STING is an interferon-stimulated gene (ISG) and its induction is crucial for the IFN-I positive feedback loop.

Indexed as

AnimalsBinding SitesCell LineImmunity, InnateInterferonsInterferon Type IMaleMembrane ProteinsMiceMice, KnockoutPromoter Regions, GeneticReceptor, Interferon alpha-betaSTAT1 Transcription FactorSTING ProteinInterferonsInterferon Type IMembrane ProteinsReceptor, Interferon alpha-betaSTAT1 Transcription FactorSTING1 protein, humanSting1 protein, mouseSTING ProteinCDNcGAMPIFNISGSTING

Identifiers

PMID25572843
PMCPMC4328747
OpenAlexW1990000646

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.