ArticleLa Radiologia medica2015
MRI findings of olivary degeneration after surgery for posterior fossa tumours in children: incidence, time course and correlation with tumour grading.
Article in La Radiologia medica, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- The Guillain-Mollaret triangle: a key player in motor coordination and control with implications for neurological disorders.Neurosurgical review · 2023Pooled it
- Unilateral inferior olivary hypertrophy in a patient with primary progressive apraxia of speech.Neuroimage. Reports · 2026Article
- Hypertrophic olivary degeneration after posterior cranial fossa tumor resection in adults: illustrative case.Journal of neurosurgery. Case lessons · 2025Article
- Hypertrophic olivary degeneration secondary to brain abscess: a case report and literature review.Frontiers in human neuroscience · 2025Article
- The Brainstem Cavernoma Case Series: A Formula for Surgery and Surgical Technique.Medicina (Kaunas, Lithuania) · 2023Article
- MR Imaging of Pediatric Brain Tumors.Diagnostics (Basel, Switzerland) · 2022Review
- Posterior Fossa Tumours in the First Year of Life: A Two-Centre Retrospective Study.Diagnostics (Basel, Switzerland) · 2022Article
- Upper Limb Motor Planning in Individuals with Cerebral Palsy Aged between 3 and 21 Years Old: A Systematic Review.Brain sciences · 2021Review
- Article
- Hypertrophic olivary degeneration in children after posterior fossa surgery. An underdiagnosed condition.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2018Review
- Magnetic resonance imaging differential diagnosis of brainstem lesions in children.World journal of radiology · 2016Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeOlivary degeneration is due to many posterior cranial fossa (PCF) lesions affecting the dentato-rubro-olivary pathway, also known as Guillain-Mollaret triangle. Triangle damage results in hyperexcitation and consequently in hypertrophy of the inferior olivary nucleus (ION). The aim of our study was to evaluate the incidence of magnetic resonance (MR) imaging changes in the ION after surgery in a large cohort of paediatric patients and to determine their correlation with tumour grade. MATERIALS AND
methodsWe retrospectively evaluated 58 patients treated surgically for PCF tumours who underwent MR imaging between 2007 and 2014, 1 week to 5 years after surgery. Histopathology revealed 29 medulloblastomas (WHO IV), 6 ependymomas (WHO II), 2 anaplastic ependymomas (WHO III) and 21 pilocytic astrocytomas (WHO I). ION MR imaging changes were correlated with surgery-to-MR interval and with tumour grading.
resultsION MR imaging changes were observed in 19/64 (33 %), and all consisted of T2 signal alterations, 15 bilateral and four unilateral, with dentate nucleus damage in all cases. Olivary enlargement was observed in few cases only (7/19). ION T2 hyperintensity was always present between 1 and 6 months after surgery with a trend to decrease, becoming faint after 1 year. The Fisher test demonstrated a significant (p = 0.005) correlation between ION MR imaging changes and high tumour grade.
conclusionsOur results demonstrate that olivary degeneration, with or without hypertrophy, is a relatively frequent consequence of posterior fossa surgery, particularly in children treated for high-grade tumours. Knowledge of this condition can prevent misdiagnoses and unnecessary investigations.
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