Evidence map›Paper›PMID 25572477›Full record

ReviewImmunotherapy2015

Adoptive cell therapy for sarcoma.

Melinda Mata, Stephen Gottschalk

Open access · greenAbstract readReview
In one paragraph

Review in Immunotherapy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Article
  6. Turning 'Cold' tumors 'Hot': immunotherapies in sarcoma.Annals of translational medicine · 2021
    Review
  7. Cellular immunotherapy: a clinical state-of-the-art of a new paradigm for cancer treatment.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2020
    Review
  8. Review
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Melinda MataCenter for Cell & Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, 1102 Bates Street, Suite 1770, Houston, TX 77030, USA.
Stephen Gottschalk
Baylor College of Medicine · USTexas Children's Hospital · US

Funding

VECTOR PRODUCTIONP01CA094237 · NCI · BAYLOR COLLEGE OF MEDICINE · PI HESLOP, HELEN E, ROONEY, CLIONA M. · 2002 to 2017
$27.8M
Training In Cell and Gene TherapyT32HL092332 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI MALCOLM K. BRENNER, Bruno Di Stefano · 2008 to 2026
$6.9M
Reprogramming of T cells for the Treatment of MelanomaR01CA173750 · NCI · DANA-FARBER CANCER INST · PI GOTTSCHALK, STEPHEN, WUCHERPFENNIG, KAI W · 2012 to 2016
$5.0M
Cancer and Stroma-Targeted Immunotherapy with a Gentically Modified DC VaccineR01CA148748 · NCI · BAYLOR COLLEGE OF MEDICINE · PI GOTTSCHALK, STEPHEN, SONG, XIAOTONG · 2011 to 2015
$1.6M
NCI NIH HHS 1R01CA148748-01A1NCI NIH HHS 1R01CA173750-01NCI NIH HHS P01 CA094237NCI NIH HHS P01CA094237NCI NIH HHS R01 CA148748NCI NIH HHS R01 CA173750NHLBI NIH HHS 5T32HL092332NHLBI NIH HHS T32 HL092332
6 · The paper itself

Abstract

Current therapy for sarcomas, though effective in treating local disease, is often ineffective for patients with recurrent or metastatic disease. To improve outcomes, novel approaches are needed and cell therapy has the potential to meet this need since it does not rely on the cytotoxic mechanisms of conventional therapies. The recent successes of T-cell therapies for hematological malignancies have led to renewed interest in exploring cell therapies for solid tumors such as sarcomas. In this review, we will discuss current cell therapies for sarcoma with special emphasis on genetic approaches to improve the effector function of adoptively transferred cells.

Indexed as

Adoptive TransferImmunity, CellularSarcomaT-LymphocytesAnimalsHumanscancer immunotherapycell therapygene transfersarcoma

Identifiers

PMID25572477
PMCPMC4331182
OpenAlexW2116962559

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.