Evidence map›Paper›PMID 25572423›Full record

ArticleBiology open2015

Proper migration and axon outgrowth of zebrafish cranial motoneuron subpopulations require the cell adhesion molecule MDGA2A.

Esther Ingold, Colette M Vom Berg-Maurer, Christoph J Burckhardt, André Lehnherr, Philip Rieder, Philip J Keller, Ernst H Stelzer, Urs F Greber, Stephan C F Neuhauss, Matthias Gesemann

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biology open, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Esther IngoldBrain Research Institute of the University Zurich and Swiss Federal Institute of Technology (ETH), Department of Biology, 8057 Zurich, Switzerland.
Colette M Vom Berg-MaurerInstitute of Molecular Life Sciences, University of Zurich, 8057 Zurich, Switzerland.
Christoph J BurckhardtInstitute of Molecular Life Sciences, University of Zurich, 8057 Zurich, Switzerland.
André LehnherrInstitute of Molecular Life Sciences, University of Zurich, 8057 Zurich, Switzerland.
Philip RiederBrain Research Institute of the University Zurich and Swiss Federal Institute of Technology (ETH), Department of Biology, 8057 Zurich, Switzerland.
Philip J KellerEMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany.
Ernst H StelzerEMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany.
Urs F GreberInstitute of Molecular Life Sciences, University of Zurich, 8057 Zurich, Switzerland.
Stephan C F NeuhaussInstitute of Molecular Life Sciences, University of Zurich, 8057 Zurich, Switzerland.
Matthias GesemannBrain Research Institute of the University Zurich and Swiss Federal Institute of Technology (ETH), Department of Biology, 8057 Zurich, Switzerland Institute of Molecular Life Sciences, University of Zurich, 8057 Zurich, Switzerland matthias.gesemann@imls.uzh.ch.
University of Zurich · CHÉcole Polytechnique Fédérale de Lausanne · CHEuropean Molecular Biology Organization · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The formation of functional neuronal circuits relies on accurate migration and proper axonal outgrowth of neuronal precursors. On the route to their targets migrating cells and growing axons depend on both, directional information from neurotropic cues and adhesive interactions mediated via extracellular matrix molecules or neighbouring cells. The inactivation of guidance cues or the interference with cell adhesion can cause severe defects in neuronal migration and axon guidance. In this study we have analyzed the function of the MAM domain containing glycosylphosphatidylinositol anchor 2A (MDGA2A) protein in zebrafish cranial motoneuron development. MDGA2A is prominently expressed in distinct clusters of cranial motoneurons, especially in the ones of the trigeminal and facial nerves. Analyses of MDGA2A knockdown embryos by light sheet and confocal microscopy revealed impaired migration and aberrant axonal outgrowth of these neurons; suggesting that adhesive interactions mediated by MDGA2A are required for the proper arrangement and outgrowth of cranial motoneuron subtypes.

Indexed as

Axon guidanceCell adhesionCell migrationCranial motoneuronsDigital light sheet microscopyMDGAZebrafish

Identifiers

PMID25572423
PMCPMC4365483
OpenAlexW2140874012

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.