ArticleThe journal of sexual medicine2015
Erectile dysfunction after sickle cell disease-associated recurrent ischemic priapism: profile and risk factors.
Article in The journal of sexual medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 60 citations in OpenAlex.
- Sympathetic hypoactivity leads to hypocontractility of the corpus cavernosum in sickle cell mice: a mechanism contributing to priapism.International journal of impotence research · 2026Article
- Update on the prevalence and pathophysiology of sickle cell priapism: a narrative review.International journal of impotence research · 2026Review
- ManAgement of pRiapiSm and its impact on outcomes: an international register (MARS study) - the first international, multicenter, observational study regarding priapism in perspective.International journal of impotence research · 2026Review
- Article
- Article
- A contemporary review of the management strategies for sickle cell disease related ischaemic and stuttering priapism.International journal of impotence research · 2025Review
- Idiopathic recurrent ischemic priapism: a review of current literature and an algorithmic approach to evaluation and management.Basic and clinical andrology · 2024Article
- Priapism: a new era.International journal of impotence research · 2024Article
- Evaluation of knowledge of priapism in sickle cell patients in Senegal.International urology and nephrology · 2023Article
- Article
- Incidence and predictors of priapism events in sickle cell anemia: a diary-based analysis.Blood advances · 2022Article
- Fertility after Curative Therapy for Sickle Cell Disease: A Comprehensive Review to Guide Care.Journal of clinical medicine · 2022Review
- Rare emergency in children: Priapism and stepwise treatment approach.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2022Article
- Fertility preservation for pediatric patients with hemoglobinopathies: Multidisciplinary counseling needed to optimize outcomes.Frontiers in endocrinology · 2022Review
- Testosterone Deficiency in Sickle Cell Disease: Recognition and Remediation.Frontiers in endocrinology · 2022Review
- External validation of the priapism impact profile in a Jamaican cohort of patients with sickle cell disease.PloS one · 2021Article
- Men with sickle cell disease experience greater sexual dysfunction when compared with men without sickle cell disease.Blood advances · 2020Article
- Resolution of Acute Priapism in Two Children With Sickle Cell Disease Who Received Nitrous Oxide.Academic emergency medicine : official journal of the Society for Academic Emergency Medicine · 2019Article
- Advances in the understanding of priapism.Translational andrology and urology · 2017Review
- Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
introductionRisk factors associated with erectile dysfunction (ED) that results from recurrent ischemic priapism (RIP) in sickle cell disease (SCD) are incompletely defined.
aimThis study aims to determine and compare ED risk factors associated with SCD and non-SCD-related "minor" RIP, defined as having ≥2 episodes of ischemic priapism within the past 6 months, with the majority (>75%) of episodes lasting <5 hours.
methodsWe performed a retrospective study of RIP in SCD and non-SCD patients presenting from June 2004 to March 2014 using the International Index of Erectile Function (IIEF), IIEF-5, and priapism-specific questionnaires.
main outcome measuresPrevalence rates and risk factor correlations for ED associated with RIP.
resultsThe study was comprised of 59 patients (40 SCD [mean age 28.2 ± 8.9 years] and 19 non-SCD [15 idiopathic and four drug-related etiologies] [mean age 32.6 ± 11.7 years]). Nineteen of 40 (47.5%) SCD patients vs. four of 19 (21.1%) non-SCD patients (39% overall) had ED (IIEF <26 or IIEF-5 <22) (P = 0.052). SCD patients had a longer mean time-length with RIP than non-SCD patients (P = 0.004). Thirty of 40 (75%) SCD patients vs. 10 of 19 (52.6%) non-SCD patients (P = 0.14) had "very minor" RIP (episodes regularly lasting ≤2 hours). Twenty-eight of 40 (70%) SCD patients vs. 14 of 19 (73.7%) non-SCD patients had weekly or more frequent episodes (P = 1). Of all patients with very minor RIP, ED was found among 14 of 30 (46.7%) SCD patients vs. none of 10 (0%) non-SCD patients (P = 0.008). Using logistic regression analysis, the odds ratio for developing ED was 4.7 for SCD patients, when controlling for RIP variables (95% confidence interval: 1.1-21.0).
conclusionsED is associated with RIP, occurring in nearly 40% of affected individuals overall. SCD patients are more likely to experience ED in the setting of "very minor" RIP episodes and are five times more likely to develop ED compared with non-SCD patients.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.